{"id":71509,"date":"2018-03-09T23:16:07","date_gmt":"2018-03-09T23:16:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-sepsis-inducida-por-la-administracion-de-lps-sobre-el-eje-gh-igf-i-papel-de-los-glucocorticoides-y-del-oxido-na%c2%adtrico\/"},"modified":"2018-03-09T23:16:07","modified_gmt":"2018-03-09T23:16:07","slug":"efecto-de-la-sepsis-inducida-por-la-administracion-de-lps-sobre-el-eje-gh-igf-i-papel-de-los-glucocorticoides-y-del-oxido-na%c2%adtrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-de-la-sepsis-inducida-por-la-administracion-de-lps-sobre-el-eje-gh-igf-i-papel-de-los-glucocorticoides-y-del-oxido-na%c2%adtrico\/","title":{"rendered":"Efecto de la sepsis inducida por la administraci\u00f3n de lps sobre el eje gh-igf-i: papel de los glucocorticoides y del \u00f3xido n\u00edtrico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa Priego Cuadra <\/strong><\/h2>\n<p>Durante la inflamaci\u00f3n del eje somatotropo est\u00e1 inhibido. La administraci\u00f3n de lps se utiliza como modelo experimental de inflamaci\u00f3n y sepsis. El lps produce una disminuci\u00f3n de los niveles s\u00e9ricos del factor de crecimiento similar a la insulina (igf-i). El igf-i est\u00e1 regulado por la hormona de crecimiento (gh) y por la prote\u00edna de uni\u00f3n a este en suero, la igfbp-3. durante la inflamaci\u00f3n se activa el eje hipot\u00e1lamo-hip\u00f3fiso-adrenal (hha) liberando gluccoritcoides y se induce la s\u00edntesis de otro regulador importante del proceso inflamatorio, el \u00f3xido n\u00edtrico (no). Ambos compuestos pueden estar mediando la inhibici\u00f3n del igf-i inducida por la administraci\u00f3n de lps.  por todo ello, los objetivos planteados fueron estudiar el efecto de la administraci\u00f3n de lps sobre el eje somatotropo y analizar el papel de la activaci\u00f3n del eje hha y del aumento del no en dicho proceso.  a nivel hipotal\u00e1mico, la administraci\u00f3n del lps, activa la expresi\u00f3n el gen de la somatostatina. Este efecto estimulador del lps sobre la somatostatina hipotal\u00e1mica est\u00e1 mediado por el aumento de la liberaci\u00f3n de no. A nivel hipofisario, el lps, a dosis bajas, tiene un efecto estimulador sobre la secreci\u00f3n de la gh. A dosis altas, disminuye la secreci\u00f3n hipofisaria de la gh.  la administraci\u00f3n del lps tiene un efecto inhibitorio directo sobre la expresi\u00f3n hep\u00e1tica de los genes del receptor de la gh, del igf-i y de la igfbp-3. La disminuci\u00f3n de la igfbp-3 circulante contribuye a la disminuci\u00f3n de los niveles s\u00e9ricos del igf-i. El aumento del no que se produce tras la administraci\u00f3n de lps ejerce un papel importante en la inhibici\u00f3n de la expresi\u00f3n hep\u00e1tica de los genes del igf-i y de la igfbo-3. El aumento de los glucorticoides tras la administraci\u00f3n de lps no media esta inhibici\u00f3n, sino que tiene un efecto protector.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la sepsis inducida por la administraci\u00f3n de lps sobre el eje gh-igf-i: papel de los glucocorticoides y del \u00f3xido n\u00edtrico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la sepsis inducida por la administraci\u00f3n de lps sobre el eje gh-igf-i: papel de los glucocorticoides y del \u00f3xido n\u00edtrico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa Priego Cuadra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M.a. Villanueva Bernu\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fern\u00e1ndez-tres guerres hern\u00e1ndez j.a. <\/li>\n<li>enrique Aguilar benitez de lugo (vocal)<\/li>\n<li> Mart\u00edn velasco Ana isabel (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa Priego Cuadra Durante la inflamaci\u00f3n del eje somatotropo est\u00e1 inhibido. La administraci\u00f3n de lps se utiliza [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,35,2820],"tags":[2380,155795,155794,55463,149251],"class_list":["post-71509","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-de-la-vida","category-genetica-humana","tag-enrique-aguilar-benitez-de-lugo","tag-fernandez-tres-guerres-hernandez-j-a","tag-m-a-villanueva-bernues","tag-martin-velasco-ana-isabel","tag-teresa-priego-cuadra"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71509"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71509\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}