{"id":71533,"date":"2018-03-09T23:16:12","date_gmt":"2018-03-09T23:16:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-asociacion-de-la-region-8q13-y-la-artritis-reumatoide-en-familias-simples-espanolas\/"},"modified":"2018-03-09T23:16:12","modified_gmt":"2018-03-09T23:16:12","slug":"estudio-de-la-asociacion-de-la-region-8q13-y-la-artritis-reumatoide-en-familias-simples-espanolas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-asociacion-de-la-region-8q13-y-la-artritis-reumatoide-en-familias-simples-espanolas\/","title":{"rendered":"Estudio de la asociacion de la region 8q13 y la artritis reumatoide en familias simples espa\u00f1olas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Jose De Agustin De Oro <\/strong><\/h2>\n<p>Investigar si la regi\u00f3n gen\u00e9tica de la hormona crh confiere susceptibilidad gen\u00e9tica para la artritis reumatoide en la poblaci\u00f3n espa\u00f1ola.  m\u00e9todos: para ello se obtuvieron muestras de dna de 121 familias simples de enfermos con artritis reumatoide y 101 controles sanos, todos ellos de la poblaci\u00f3n espa\u00f1ola. Se examinaron dos microsat\u00e9lites, crhra1 y crhra2, localizado a 20 y 25 kb respectivamente del gen de la crh utilizando un nuevo dise\u00f1o m\u00faltiplex. Se estudi\u00f3 el desequilibrio de ligamiento y la asociaci\u00f3n entre los marcadores utilizando el tres de transmisi\u00f3n de desequilibrio (tdt) implementado en el software transmit. Resultados: los dos marcadores estaban en equilibrio de hardy-weinberg y se observ\u00f3 desequilibrio de ligamiento significativo entre ellos en la poblaci\u00f3n espa\u00f1ola. Ninguno de los alelos polim\u00f3rficos de los marcadores crhra1 y crhra2 ni los haplotipos resultantes estaban asociados significativamente a la artritis reumatoide. El haplotipo asociado en la poblaci\u00f3n del reino unido (crhra1*10; crhra2*14) fue poco transmitido en los pacientes con artritis reumatoide (12 obs versus 17,43 exp), pero las diferencias no fueron estad\u00edsticamente significativas (p> 0,05). conclusiones: es el primer estudio de la asociaci\u00f3n entre la regi\u00f3n gen\u00e9tica de la hormona crh y la artritis reumatoide y sugiere que el gen de las crh puede no estar involucrado en la patog\u00e9nesis de la artritis reumatoide en la poblaci\u00f3n espa\u00f1ola. Son necesarios m\u00e1s estudios en otras poblaciones para comprender la contribuci\u00f3n real de esta regi\u00f3n genomica en la susceptibilidad a la artritis reumatoide.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la asociacion de la region 8q13 y la artritis reumatoide en familias simples espa\u00f1olas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la asociacion de la region 8q13 y la artritis reumatoide en familias simples espa\u00f1olas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Jose De Agustin De Oro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sara Marsal Barril<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Jose De Agustin De Oro Investigar si la regi\u00f3n gen\u00e9tica de la hormona crh confiere susceptibilidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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