{"id":71545,"date":"2018-03-09T23:16:12","date_gmt":"2018-03-09T23:16:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-poblacional-de-benznidazol-en-pacientes-mexicanos-con-enfermedad-de-chagas\/"},"modified":"2018-03-09T23:16:12","modified_gmt":"2018-03-09T23:16:12","slug":"farmacocinetica-poblacional-de-benznidazol-en-pacientes-mexicanos-con-enfermedad-de-chagas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-poblacional-de-benznidazol-en-pacientes-mexicanos-con-enfermedad-de-chagas\/","title":{"rendered":"Farmacocinetica poblacional de benznidazol en pacientes mexicanos con enfermedad de chagas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Peregrina Lucano Alejandro Aaron <\/strong><\/h2>\n<p>La enfermedad de chagas es una parasitosis end\u00e9mica del continente americano producida por el tripanosoma cruzi. En m\u00e9xico, la enfermedad de chagas no est\u00e1 reconocida oficialmente como un problema de salud p\u00fablica a pesar de su alta preValencia. El tripanomicida m\u00e1s utilizado para el tratamiento de esta enfermedad es el benznidazol, de cuya farmacocin\u00e9tica existe muy escasa informaci\u00f3n.  se ha desarrollado y validado una t\u00e9cnica anal\u00edtica de hplc con detecci\u00f3n uv para la determinaci\u00f3n de las concentraciones s\u00e9ricas de benznidazol.  se ha estudiado la cin\u00e9tica de benizdazol en dosis \u00fanica en voluntarios sanos para obtener un modelo de poblaci\u00f3n que permitiera la individualizaci\u00f3n de los par\u00e1metros cin\u00e9ticos de benznidazol en los pacientes con enfermedad de chagas. Los valores de los par\u00e1metros farmacocin\u00e9ticos estimados fueron; ka: 1.15 h-1, cl\/f: 2.04 l\/h y vd\/f: 49.4 l.  posteriormente se ha estudiado la farmacocin\u00e9tica de benznidazol  en una poblaci\u00f3n de 50 pacientes con enfermedad de chagas sometidos a monitorizaci\u00f3n rutinaria de los niveles s\u00e9ricos a los que les administr\u00f3 una dosis inicial de mantenimiento de 5 mg\/kg\/d\u00eda durante 30 d\u00edas. El modelo farmacocin\u00e9tico poblacional de efectos mixtos desarrollado utiliza como covariables la edad y el peso del paciente y permite la individualizaci\u00f3n del tratamiento con benznidazol en este tipo de pacientes.  paralelamente, se ha realizado un estudio de optimizaci\u00f3n de tiempos de muestreo para la estimaci\u00f3n eficaz de par\u00e1metros farmacocin\u00e9ticosy un estudio poblacional con t\u00e9cnicas de simulaci\u00f3n de montecarlo para optimizar las condiciones de monitorizaci\u00f3n del benznidazol.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocinetica poblacional de benznidazol en pacientes mexicanos con enfermedad de chagas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocinetica poblacional de benznidazol en pacientes mexicanos con enfermedad de chagas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Peregrina Lucano Alejandro Aaron <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Martinez Lanao<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>Mar\u00eda eugenia M\u00e9ndez esteban (vocal)<\/li>\n<li>isabel Arranz pe\u00f1a (vocal)<\/li>\n<li> Celta fal\u00ed\u00a7ao ramos ferreira amilcar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Peregrina Lucano Alejandro Aaron La enfermedad de chagas es una parasitosis end\u00e9mica del continente americano producida por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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