{"id":71567,"date":"2004-01-12T00:00:00","date_gmt":"2004-01-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-alteraciones-geneticas-y-epigeneticas-involucradas-en-el-desarrollo-de-oligodendrogliomas\/"},"modified":"2004-01-12T00:00:00","modified_gmt":"2004-01-12T00:00:00","slug":"papel-de-las-alteraciones-geneticas-y-epigeneticas-involucradas-en-el-desarrollo-de-oligodendrogliomas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-de-las-alteraciones-geneticas-y-epigeneticas-involucradas-en-el-desarrollo-de-oligodendrogliomas\/","title":{"rendered":"Papel de las alteraciones gen\u00e9ticas y epigen\u00e9ticas involucradas en el desarrollo de oligodendrogliomas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M.eva Alonso Fernandez <\/strong><\/h2>\n<p>El proceso cancer\u00edgeno es un proceso complejo resultante de varios eventos sucesivos. El principal es la proliferaci\u00f3n de una o un grupo de c\u00e9lulas que da lugar a un acumulo celular llamado tumor. La g\u00e9nesis de \u00e9ste implica un aumento de alteraciones moleculares durante un determinado periodo hasta el  momento en el que se hace evidente.  los oligodendrogliomas son tumores derivados de las c\u00e9lulas de la oligodendrogl\u00eda. tienen una incidencia de aproximadamente el 5% de todos los tumores cerebrales primarios y de un loa 25% de los gliomas intracraneales de acuerdo con la organizaci\u00f3n mundial de la salud (oms), los oligodendrogliomas se dividen en funci\u00f3n de su grado histopat\u00f3logico y de malignidad en:  oligodendrogliomas de grado ti, oligodendrogliomas de grado id o anapl\u00e1sico y oligoastrocitomas o tumores mixtos (grado tiy id) con componente de la serie astroc\u00edtica y oligodendroglial.  los estudios mutacionales y citogen\u00e9ticos no han conseguido explicar totalmente la g\u00e9nesis y progresi\u00f3n de oligodendrogliomas. Aunque se ha asociado la p\u00e9rdida de heterocigosidad de regiones cromos\u00f3micas espec\u00edficas con la progresi\u00f3n tumoral hacia formas de grado id, hasta ahora no se han  identificado con claridad de entre los posibles genes candidatos, aquellos responsables de esta progresi\u00f3n. Los estudios citogen\u00e9tico-moleculares representaron la primera aproximaci\u00f3n al conocimiento de la base gen\u00e9tica implicada en el desarrollo de oligodendrogliomas. Las alteraciones m\u00e1s comunes son las p\u00e9rdidas al\u00e9licas en 1p y 19q o la combinaci\u00f3n de ambas. la frecuente coincidencia de las p\u00e9rdidas de 1p y 19q sugiere un efecto sin\u00e9rgico de ambas alteraciones confiriendo una ventaja selectiva a los oligodendrocitos. Oncosupresores localizados en lp que podr\u00edan ser genes diana involucrados en el  proceso de formaci\u00f3n de oligodendrogliomas son por ejemplo p1[jnk4c,tp73, patched2, rlz1 y kif1b. Las p\u00e9rdidas en 19q indican una ventaj<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las alteraciones gen\u00e9ticas y epigen\u00e9ticas involucradas en el desarrollo de oligodendrogliomas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las alteraciones gen\u00e9ticas y epigen\u00e9ticas involucradas en el desarrollo de oligodendrogliomas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M.eva Alonso Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Antonio Rey Herranz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: c\u00e9sar Benito jim\u00e9nez <\/li>\n<li>Alberto Isla guerrero (vocal)<\/li>\n<li>m.josefa Bello gonzalez (vocal)<\/li>\n<li>Jos\u00e9 Luis Sarasa corral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M.eva Alonso Fernandez El proceso cancer\u00edgeno es un proceso complejo resultante de varios eventos sucesivos. El principal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,962,4578,40433,4275],"tags":[37065,38128,29918,83755,155898,155899],"class_list":["post-71567","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-genetica","category-ingenieria-genetica","category-neurobiologia-molecular","category-neurociencias","tag-alberto-isla-guerrero","tag-cesar-benito-jimenez","tag-jose-luis-sarasa-corral","tag-juan-antonio-rey-herranz","tag-m-eva-alonso-fernandez","tag-m-josefa-bello-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71567"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71567\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}