{"id":7157,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/estimacion-de-la-variabilidad-farmacocinetica-inter-e-intraindividual-aplicando-modelos-lineales-valproato-carbamazepina-y-fenitoina\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"estimacion-de-la-variabilidad-farmacocinetica-inter-e-intraindividual-aplicando-modelos-lineales-valproato-carbamazepina-y-fenitoina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estimacion-de-la-variabilidad-farmacocinetica-inter-e-intraindividual-aplicando-modelos-lineales-valproato-carbamazepina-y-fenitoina\/","title":{"rendered":"Estimacion de la variabilidad farmacocinetica inter e intraindividual aplicando modelos lineales: valproato, carbamazepina y fenitoina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar Calvo Malvar <\/strong><\/h2>\n<p>Se evalua una mezcla de 118 pacientes epilepticos a tratamiento con valproato, carbamazepina y\/o fenitoina para la estimacion de la variabilidad inter e intraindividual del aclaramiento aparente empleando un modelo log-lineal. Se justifica el modelo lineal 1n c= i+s. Dosis propuesto empiricamente por wagner (1985) para farmacos con cinetica de michaelis-menten. El modelo log-lineal con efectos aleatorios anidado explica de manera satisfactoria la variabilidad inter e intraindividual del aclaramiento aparente del valproato y de la carbamazepina. Se propone el coeficiente de correlacion intraclase como medida de las variabilidades relativas inter e intraindividual, habiendose estimado un valor de 0,70 para ambos farmacos. Con valores superiores o similares a 0,70 el ajuste posologico puede realizarse exclusivamente a partir de las determinaciones realizadas en el propio paciente. Se justifica el modelo log-lineal propuesto por wagner, demostrandose que la pendiente s=vmax\/(vmax-d)d y la ordenada y abcisa en el punto de inflexion son vmax\/2 y 1nkm respectivamente. Se pone de manifiesto la adecuadibilidad del modelo farmacoestadistico 1n c= i+s. D+  i+  ij habiendose establecido un valor medio de s para nuestra poblacion de 3,01.10 -3.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estimacion de la variabilidad farmacocinetica inter e intraindividual aplicando modelos lineales: valproato, carbamazepina y fenitoina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estimacion de la variabilidad farmacocinetica inter e intraindividual aplicando modelos lineales: valproato, carbamazepina y fenitoina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar Calvo Malvar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matias A. Llabres Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ram\u00f3n Mart\u00ednez Pacheco <\/li>\n<li> Hernandez Perez Miguel A. (vocal)<\/li>\n<li>William Barr (vocal)<\/li>\n<li> Molina Martinez Irene T. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar Calvo Malvar Se evalua una mezcla de 118 pacientes epilepticos a tratamiento con valproato, carbamazepina y\/o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,957,9915],"tags":[26006,26004,26005,26008,3307,26007],"class_list":["post-7157","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-la-laguna","tag-hernandez-perez-miguel-a","tag-mar-calvo-malvar","tag-matias-a-llabres-Martinez","tag-molina-Martinez-irene-t","tag-ramon-Martinez-pacheco","tag-william-barr"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7157"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7157\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}