{"id":71595,"date":"2004-02-12T00:00:00","date_gmt":"2004-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-funcion-citoquinica-intracelular-en-la%c2%adquido-asca%c2%adtico-no-neutroca%c2%adtico\/"},"modified":"2004-02-12T00:00:00","modified_gmt":"2004-02-12T00:00:00","slug":"estudio-de-la-funcion-citoquinica-intracelular-en-la%c2%adquido-asca%c2%adtico-no-neutroca%c2%adtico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-funcion-citoquinica-intracelular-en-la%c2%adquido-asca%c2%adtico-no-neutroca%c2%adtico\/","title":{"rendered":"\u00abestudio de la funci\u00f3n citoquinica intracelular en l\u00edquido asc\u00edtico no neutroc\u00edtico\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Rodr\u00edguez Borja <\/strong><\/h2>\n<p>El adn bacteriano se comporta como una mol\u00e9cula activadora del sistema inmune. Los \u00faltimos trabajos confirman que se trata de una activador mayor. en estudios previos hemos demostrado que en determinados pacientes cirr\u00f3ticos que desarrollan una ascitis en cuyo l\u00edquido no crecen bacterias mediante las t\u00e9cnicas de cultivo habituales pero que cl\u00ednicamente se comportan como pacientes con cultivo positivo, se detecta, sin embargo, en ellos, la presencia de adn bacteriano. Dada la condici\u00f3n del adn bacteriano como mol\u00e9cula inmunoreguladora en estos l\u00edquidos asc\u00edticos \u00abest\u00e9riles\u00bb, debe existir una activaci\u00f3n celular que soporte la respuesta inmune. Dicha activaci\u00f3n debe tener lugar a trav\u00e9s de la producci\u00f3n de citoquinas y dentro de \u00e9stas, la producci\u00f3n de citoquinas proinflamatorias tendr\u00e1 un lugar preponderante.Los objetivos de nuestro trabajo fueron los siguientes: 1) optimizar un m\u00e9todo para la detecci\u00f3n de citoquinas intracelulares en monocito\/macr\u00f3fagos de l\u00edquido asc\u00edtico mediante t\u00e9cnicas de citometr\u00eda de flujo; 2) demostrar el origen celular de las citoquinas proinflamatorias (il-1b, il-8, il-6 y tnfa) en l\u00edquidos asc\u00edticos \u00abest\u00e9riles\u00bb no neutroc\u00edticos (laenn); 3) identificar si existe un estado de \u00abpreactivaci\u00f3n\u00bb celular ex vivo en los laenn  adn bacteriano (+) frente a laenn adn bacteriano (-). Consideramos que existe un estado de \u00abpreactivaci\u00f3n\u00bb celular cuando los niveles de las distintas citoquinas intracelulares evaluadas en los cultivos no estimulados artificialmente (con lps) son significativamente superiores a aquellos evaluados en las muestras del grupo control; 4) detectar el grado de reserva funcional celular in vitro en los laenn. Consideramos que existe una reserva funcional celular, tanto de s\u00edntesis como de secreci\u00f3n, cuando los niveles de las distintas citoquinas intracelulares evaluadas tras la adici\u00f3n al cultivo de lps son superiores a aquellos evaluados en los cultivos no estimulados ar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abestudio de la funci\u00f3n citoquinica intracelular en l\u00edquido asc\u00edtico no neutroc\u00edtico\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abestudio de la funci\u00f3n citoquinica intracelular en l\u00edquido asc\u00edtico no neutroc\u00edtico\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Rodr\u00edguez Borja <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Mu\u00f1oz Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin de Juan  herrero <\/li>\n<li>Jos\u00e9 Francisco Such ronda (vocal)<\/li>\n<li> Jos\u00e9 Miguel semere ortells (vocal)<\/li>\n<li>l\u00f3pez Juan  cabello (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Rodr\u00edguez Borja El adn bacteriano se comporta como una mol\u00e9cula activadora del sistema inmune. Los \u00faltimos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[19166,160,2148,35,9,491,1737,450,139,156,17],"tags":[4342,155953,8669,64033,155954,155955],"class_list":["post-71595","post","type-post","status-publish","format-standard","hentry","category-alicante","category-bioquimica","category-bioquimica-inmunologica","category-ciencias-de-la-vida","category-ciencias-medicas","category-gastroenterologia","category-inmunologia","category-inmunopatologia","category-medicina-interna","category-patologia","category-quimica","tag-carlos-munoz-ruiz","tag-enrique-rodriguez-borja","tag-joaquin-de-juan-herrero","tag-jose-francisco-such-ronda","tag-jose-miguel-semere-ortells","tag-lopez-juan-cabello"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71595"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71595\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}