{"id":71615,"date":"2004-02-12T00:00:00","date_gmt":"2004-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-aceite-de-oliva-y-sus-componentes-sobre-el-desarrollo-de-la-aterosclerosis-en-el-raton-ingenierizado-carente-de-la-apolipoprotea%c2%adna-e\/"},"modified":"2004-02-12T00:00:00","modified_gmt":"2004-02-12T00:00:00","slug":"efecto-del-aceite-de-oliva-y-sus-componentes-sobre-el-desarrollo-de-la-aterosclerosis-en-el-raton-ingenierizado-carente-de-la-apolipoprotea%c2%adna-e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/efecto-del-aceite-de-oliva-y-sus-componentes-sobre-el-desarrollo-de-la-aterosclerosis-en-el-raton-ingenierizado-carente-de-la-apolipoprotea%c2%adna-e\/","title":{"rendered":"Efecto del aceite de oliva y sus componentes sobre el desarrollo de la aterosclerosis en el rat\u00f3n ingenierizado carente de la apolipoprote\u00edna e."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Acin Martinez <\/strong><\/h2>\n<p>1. El aporte de una elevada cantidad de grasa monoinsaturada en forma de aceite de oliva virgen en la dieta no eleva la lesi\u00f3n arterioscler\u00f3tica con respecto a una dieta rica en carbohidratos, en el rat\u00f3n carente de la apolipoprote\u00edna e. Sin embargo, este efecto es suprimido por la presencia de colesterol. 2. Los componentes minoritarios del aceite de juegan un papel importante en la regulaci\u00f3n del nivel de triglic\u00e9ridos y colesterol plasm\u00e1tico, as\u00ed como en la modificaci\u00f3n de la expresi\u00f3n g\u00e9nica hep\u00e1tica y en la regulaci\u00f3n de la lesi\u00f3n arterioscler\u00f3tica. 3. Una dieta enriquecida en aceite de orujo extra\u00eddo por procedimientos mec\u00e1nicos disminuye la lesi\u00f3n con respecto a una dieta enriquecida en aceite de oliva refinado y eleva la expresi\u00f3n de orosomucoide lo cual est\u00e1 asociado con una menor expresi\u00f3n de mac-1 de monocitos circulantes. 4. El suplemento de la dieta con escualeno produce un ac\u00famulo del mismo en el h\u00edgado de los ratones machos carentes de apo e y est\u00e1 correlacionado con una disminuci\u00f3n de la grasa hep\u00e1tica y de la lesi\u00f3n arterial. Por el contrario, en las hembras, este suplemento no induce ac\u00famulo de escualeno en el h\u00edgado, asociado a una ligera esteatosis hep\u00e1tica y sin cambios en la lesi\u00f3n ateroscler\u00f3tica.  Estos resultados indican que el sexo es un factor importante a la hora de valorar el comportamiento de este modelo en las distintas condiciones experimentales. 5. El suplemento de la dieta con hidroxitirosol incrementa la lesi\u00f3n en el rat\u00f3n carente de apo e, incremento que est\u00e1 correlacionado con la expresi\u00f3n de mac-1 en los monocitos circulantes, especialmente en machos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del aceite de oliva y sus componentes sobre el desarrollo de la aterosclerosis en el rat\u00f3n ingenierizado carente de la apolipoprote\u00edna e.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del aceite de oliva y sus componentes sobre el desarrollo de la aterosclerosis en el rat\u00f3n ingenierizado carente de la apolipoprote\u00edna e. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Acin Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas De La Osada Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: valentina Ruiz guti\u00e9rrez <\/li>\n<li>Ana Cenarro lagunas (vocal)<\/li>\n<li>Mar\u00eda isabel Covas planells (vocal)<\/li>\n<li>pedro Mata lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Acin Martinez 1. El aporte de una elevada cantidad de grasa monoinsaturada en forma de aceite [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,964,13610],"tags":[28705,66718,69561,2099,155994,4427],"class_list":["post-71615","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-lipidos","category-zaragoza","tag-ana-cenarro-lagunas","tag-jesus-de-la-osada-garcia","tag-maria-isabel-covas-planells","tag-pedro-mata-lopez","tag-sergio-acin-Martinez","tag-valentina-ruiz-gutierrez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71615","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71615"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71615\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}