{"id":7165,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/diseno-y-optimizacion-de-un-sistema-de-cesion-controlada-de-metadona\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"diseno-y-optimizacion-de-un-sistema-de-cesion-controlada-de-metadona","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-y-optimizacion-de-un-sistema-de-cesion-controlada-de-metadona\/","title":{"rendered":"Dise\u00f1o y optimizacion de un sistema de cesion controlada de metadona."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Araceli Delgado Hernandez <\/strong><\/h2>\n<p>Se plantea el desarrollo de una formulacion de cesion sostenida de metadona a base de microesferas de polilactico para que libere el farmaco en 7 dias. Para abordar el objetivo planteado se optimiza la cesion de metadona a traves de 2 estrategias: una tomando como parametros de optimizacion la cesion inicial (2h) y la funcion objetivo y la segunda empleando la cantidad maxima cedida, la velocidad media de cesion y la cantidad de metadona cedida en las primeras 24 horas.  la formulacion optima se encuentra entre dos formulaciones elaboradas.  tambien se estudia la degradacion del polimero durante los ensayos de cesion, resultando que para polimeros de peso molecular elevado, la degradacion tiene lugar en las primeras horas por un mecanismo de rotura aleatorio y no aleatorio, para a partir de un cierto tiempo predominar el mecanismo de rotura aleatorio.  las formulaciones se almacenan durante un a\u00f1o con el fin de estudiar su estabilidad. El peso molecular en numero del polilactico disminuye pero no afecta de forma importante a la cesion de metadona.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y optimizacion de un sistema de cesion controlada de metadona.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y optimizacion de un sistema de cesion controlada de metadona. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Araceli Delgado Hernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matias A. Llabres Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Cadorniga Carro <\/li>\n<li> Alonso Fernandez M. Jos\u00e9 (vocal)<\/li>\n<li>Julio San Roman Del Barrio (vocal)<\/li>\n<li>Obdulia Munguia Lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Araceli Delgado Hernandez Se plantea el desarrollo de una formulacion de cesion sostenida de metadona a base [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189,957,9915,3304],"tags":[3219,26028,3081,26005,26029,342],"class_list":["post-7165","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-la-laguna","category-preparacion-de-farmacos","tag-alonso-fernandez-m-jose","tag-araceli-delgado-hernandez","tag-julio-san-roman-del-barrio","tag-matias-a-llabres-Martinez","tag-obdulia-munguia-lopez","tag-rafael-cadorniga-carro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7165"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7165\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}