{"id":7166,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/hacia-la-sintesis-de-la-ciguatoxina-construccion-convergente-via-oxatiaciclos-fusionados-en-trans\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"hacia-la-sintesis-de-la-ciguatoxina-construccion-convergente-via-oxatiaciclos-fusionados-en-trans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ingenieria-y-tecnologia-quimicas\/hacia-la-sintesis-de-la-ciguatoxina-construccion-convergente-via-oxatiaciclos-fusionados-en-trans\/","title":{"rendered":"Hacia la sintesis de la ciguatoxina. construccion convergente via oxatiaciclos fusionados en trans."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Diaz Diaz M. Teresa <\/strong><\/h2>\n<p>Esta memoria constituye una aportacion a la sintesis total de la ciguatoxina, polieter bioactivo de origen marino que se engloba dentro de un importante grupo de toxinas de interes farmacologico. El estudio se centra en la sintesis del fragmento def de la molecula de ciguatoxina, que presenta tres eteres ciclicos unidos entre si mediante fusion trans. Se analiza la viabilidad de una ruta sintetica convergente, que permita el acoplamiento de diferentes subunidades, generando al mismo tiempo nuevos ciclos. En el primer capitulo se describe la preparacion de sistemas de oxepano adecuadamente funcionalizados en su forma meso y asimetrizacion de dichas subunidades mediante reacciones catalizadas por enzimas. En el segundo y tercer capitulos se estudia el acoplamiento de subunidades mediante la formacion de oxatiaciclos, precursores de los oxociclos insaturados presentes en la molecula de ciguatoxina.  oxidacion del azufre a sulfona y reaccion de ramberg-backlund permite la generacion de dobles enlaces en los pasos finales de la sintesis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hacia la sintesis de la ciguatoxina. construccion convergente via oxatiaciclos fusionados en trans.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hacia la sintesis de la ciguatoxina. construccion convergente via oxatiaciclos fusionados en trans. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Diaz Diaz M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Delgado Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Waldemar Adam <\/li>\n<li>Victor Sotero Martin Garcia (vocal)<\/li>\n<li>Jos\u00e9 Joaquin Barluenga Mur (vocal)<\/li>\n<li>Miguel \u00e1ngel Miranda Alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diaz Diaz M. Teresa Esta memoria constituye una aportacion a la sintesis total de la ciguatoxina, polieter [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,305,9915,9297],"tags":[26030,3282,8263,8213,3101,26031],"class_list":["post-7166","post","type-post","status-publish","format-standard","hentry","category-ciencias-tecnologicas","category-ingenieria-y-tecnologia-quimicas","category-la-laguna","category-sintesis-quimica","tag-diaz-diaz-m-teresa","tag-jose-joaquin-barluenga-mur","tag-julio-delgado-martin","tag-miguel-angel-miranda-alonso","tag-victor-sotero-martin-garcia","tag-waldemar-adam"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=7166"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/7166\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=7166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=7166"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=7166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}