{"id":71664,"date":"2004-03-12T00:00:00","date_gmt":"2004-03-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-experimental-en-rata-sobre-proteccion-de-anastomosis-de-colon-de-alto-riesgo-por-isquemia-con-adhesivo-de-fibrina-0-antagonista-de-serotonina\/"},"modified":"2004-03-12T00:00:00","modified_gmt":"2004-03-12T00:00:00","slug":"estudio-experimental-en-rata-sobre-proteccion-de-anastomosis-de-colon-de-alto-riesgo-por-isquemia-con-adhesivo-de-fibrina-0-antagonista-de-serotonina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-abdominal\/estudio-experimental-en-rata-sobre-proteccion-de-anastomosis-de-colon-de-alto-riesgo-por-isquemia-con-adhesivo-de-fibrina-0-antagonista-de-serotonina\/","title":{"rendered":"Estudio experimental en rata sobre proteccion de anastomosis de colon de alto riesgo por isquemia con adhesivo de fibrina 0 antagonista de serotonina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cebollero Benito Mar\u00eda Del Pilar <\/strong><\/h2>\n<p>La dehiscencia de la anastomosis es una de las complicaciones m\u00e1s importantes en la cirug\u00eda del aparato digestivo con una alta morbimortalidad. Actualmente se intervienen pacientes con edad m\u00e1s avanzada y patolog\u00eda asociada que conlleva una alteraci\u00f3n en la vascularizaci\u00f3n.  puede existir una hipersensibilidad a la serotonina en pacientes con alteraci\u00f3n en la vascularizaci\u00f3n, de modo que los antagonistas de la serotonina pueden mejorar la microcirculaci\u00f3n. hipotesis de trabajo: 1.- El adhesivo de fibrina protege las anastomosis realizadas sobre colon isqu\u00e9mico de rata. 2.- La administraci\u00f3n perioperatoria de ketanserina protege las anastomosis en colon isqu\u00e9mico de rata. objetivos principales: 1.- Determinar si el adhesivo de fibrina aumenta la resistencia de la sutura. 2.- Determinar si la administraci\u00f3n de ketanserina aumenta la resistencia de la sutura.  objetivos secundarios: 1: valorar si el adhesivo de fibrina influye en la aparici\u00f3n de adherencias postoperatorias, en la s\u00edntesis de col\u00e1geno, en la inflamaci\u00f3n y en la fibrosis de la anastomosis en colon isqu\u00e9mico. 2.- Valorar si la administraci\u00f3n de ketanserina aumenta la vascularizaci\u00f3n en la anastomosis de colon isqu\u00e9mico. material y metodo: se intervinieron 60 ratas macho tipo wistar divididas en tres grupos: grupo a (sutura simple), grupo b (sutura simple con adhesivo de fibrina mezclado con cefotaxima y clindamicina) y grupo c (sutura simple y administraci\u00f3n de 1 mg\/k de ketanserina el d\u00eda de la intervenci\u00f3n y dos primeros d\u00edas de postoperatorio ). En todas se realiz\u00f3 isquemia del colon izquierdo. La mitad de las ratas de cada grupo se sacrificaron a 3\u00c2\u00b0 d\u00eda y la otra mitad a 7\u00c2\u00b0 d\u00eda de postoperatorio. Se realiza valoraci\u00f3n quir\u00fargica ( medici\u00f3n de la presi\u00f3n de estallido ), bioqu\u00edmica ( an\u00e1lisis del contenido de hidroxiprolina por cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n ) y anatomopatol\u00f3gica ( determinaci\u00f3n de inflamaci\u00f3n, fibrosis y vascularizaci\u00f3n). El est<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio experimental en rata sobre proteccion de anastomosis de colon de alto riesgo por isquemia con adhesivo de fibrina 0 antagonista de serotonina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio experimental en rata sobre proteccion de anastomosis de colon de alto riesgo por isquemia con adhesivo de fibrina 0 antagonista de serotonina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cebollero Benito Mar\u00eda Del Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Esarte Muni\u00e1in Jes\u00fas Mar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Arribas llorente <\/li>\n<li> Garc\u00eda criado Francisco Javier (vocal)<\/li>\n<li>\u00e1ngel G\u00f3mez palacios (vocal)<\/li>\n<li> Ruiz liso Juan  Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cebollero Benito Mar\u00eda Del Pilar La dehiscencia de la anastomosis es una de las complicaciones m\u00e1s importantes 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