{"id":71693,"date":"2004-09-12T00:00:00","date_gmt":"2004-09-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senales-de-calcio-y-de-exocitosis-generadas-por-acetilcolina-colina-y-potasio-en-la-celula-cromafa%c2%adn\/"},"modified":"2004-09-12T00:00:00","modified_gmt":"2004-09-12T00:00:00","slug":"senales-de-calcio-y-de-exocitosis-generadas-por-acetilcolina-colina-y-potasio-en-la-celula-cromafa%c2%adn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/senales-de-calcio-y-de-exocitosis-generadas-por-acetilcolina-colina-y-potasio-en-la-celula-cromafa%c2%adn\/","title":{"rendered":"Se\u00f1ales de calcio y de exocitosis generadas por acetilcolina, colina y potasio, en la  c\u00e9lula cromaf\u00edn"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Fuentealba Arcos <\/strong><\/h2>\n<p>La c\u00e9lula cromaf\u00edn de la m\u00e9dula suprarrenal expresa canales de calcio voltaje-dependientes de los  subtipos l, n, p\/q, r y t (garc\u00eda y col., 2000; bournaud y col., 2001). En distintos tipos neuronales se conoce la distribuci\u00f3n diferencial de estos subtipos de canales; por ejemplo, los canales n y p\/q predominan en las dendritas apicales y terminales ax\u00f3nicos que hacen sinapsis en las dendritas de otras neuronas (westenbroek y col., 1992), a diferencia de los del subtipo l, que han sido descritos en mayor densidad en las regiones proximales de las dendritas y en el soma de las neuronas (ahlijanian y col., 1990; westenbroek y col., 1990; westenbroek y col., 1992; waterman, 1997; timmermann y col., 2002).  la cuesti\u00f3n radica en si esta especializaci\u00f3n geogr\u00e1fica de los canales est\u00e1 asociada o no a funciones espec\u00edficas, como por ejemplo la expresi\u00f3n g\u00e9nica, la activaci\u00f3n enzim\u00e1tica o la secreci\u00f3n de neurotransmisores; procesos que podr\u00edan activarse de forma distinta en funci\u00f3n del ca2+ que entra por un determinado subtipo de canal de ca2+.  en nuestro modelo experimental, la c\u00e9lula cromaf\u00edn bovina en cultivo (que si recordamos tiene una forma esf\u00e9rica, a diferencia de su forma poli\u00e9drica in vivo; ver figura 1), la posible distribuci\u00f3n especializada de los canales de ca2+ es m\u00e1s cr\u00edtica y algo menos clara. A mediados de los a\u00f1os 90 nuestro grupo describi\u00f3 que en cultivos primarios de c\u00e9lulas cromafines bovinas, los canales de ca2+ de  los subtipos l y p\/q ejercen un control predominante de la secreci\u00f3n de catecolaminas; a diferencia del ca2+ que entra por el canal n, que a\u00fan siendo protagonista de la g\u00e9nesis de un 30% de las corrientes totales, no parece participar en la exocitosis (l\u00f3pez y col., 1994). Adem\u00e1s, utilizando anticuerpos espec\u00edficos frente a prote\u00ednas de la maquinaria exocit\u00f3tica, nuestro grupo ha observado una polarizaci\u00f3n de las ves\u00edculas de secreci\u00f3n en c\u00e9lulas cromafines bovinas (cuchi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1ales de calcio y de exocitosis generadas por acetilcolina, colina y potasio, en la  c\u00e9lula cromaf\u00edn<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1ales de calcio y de exocitosis generadas por acetilcolina, colina y potasio, en la  c\u00e9lula cromaf\u00edn <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Fuentealba Arcos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>Francisco Sala merchan (vocal)<\/li>\n<li>Javier Alvarez martin (vocal)<\/li>\n<li>ricardo Borges jurado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Fuentealba Arcos La c\u00e9lula cromaf\u00edn de la m\u00e9dula suprarrenal expresa canales de calcio voltaje-dependientes de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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