{"id":71715,"date":"2004-10-12T00:00:00","date_gmt":"2004-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/apoptosis-en-el-liquen-plano-oral\/"},"modified":"2004-10-12T00:00:00","modified_gmt":"2004-10-12T00:00:00","slug":"apoptosis-en-el-liquen-plano-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/apoptosis-en-el-liquen-plano-oral\/","title":{"rendered":"Apoptosis en el liquen plano oral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Bascones Ilundain <\/strong><\/h2>\n<p>El lp es una enfermedad mucocut\u00e1nea cr\u00f3nica inflamatoria, de etiolog\u00eda desconocida y naturaleza autoinmune en la que se produce una agresi\u00f3n t linfocitaria dirigida hacia las c\u00e9lulas basales del epitelio de la mucosa oral. La apoptosis es un fen\u00f3meno celular de enorme trascendencia por el que las c\u00e9lulas mueren tomando parte activa en su propia eluminaci\u00f3n. Se ha demostrado que los mecanismos apopt\u00f3ticos de destrucci\u00f3n celular tienen lugar en esta enfermedad existiendo determinadas prote\u00ednas relacionadas con este tipo de muerte celular. As\u00ed mismo se conoce que la apoptosis est\u00e1 incrementada en el lpo in situ respecto ala mucosa oral normal. Se debe estudiar , en esta lesiones con posibilidad de malignizarse, el significado de la expresi\u00f3n de los reguladores del ciclo celular, cuya alteraci\u00f3n ha demostrado ser de gran trascendencia en el proceso de transformaci\u00f3n maligna en diversos tejidos.  por todo ello nos hemos planteado los siguientes objetivos: establecer la concordancia de las alteraciones histopatol\u00f3gicas observadas en el lpo como marcadores de apoptosis; conocer la importancia cuantitativa de los fen\u00f3menos apopt\u00f3ticos en el lpo; comprobar la validez de las t\u00e9cnicas de tunel y de la perixidasa-antiperoxidasa para la detecci\u00f3n de la muerte celular programada en el lpo; y establecer una hip\u00f3tesis etiopatog\u00e9nica sobre la influencia de los mecanismos apopt\u00f3ticos y de control del ciclo celular en el proceso de malignizaci\u00f3n del lpo , que sirva de punto de partida para el estudio de este importante evento.  las conclusiones han sido: que la degeneraci\u00f3n vacuolizante de la capa basal epitelial no es una evidencia histopatol\u00f3gica absoluta de apoptosis; la muerte por apoptosis en el lpo no genera necesariamente la transformaci\u00f3n celular en cuerpos coloides o de civatte; la apoptosis, la detenci\u00f3n y la senescencia celular han resultado ser, en nuestro  estudio , mecanismos cuantitativamente poco importantes en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Apoptosis en el liquen plano oral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Apoptosis en el liquen plano oral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Bascones Ilundain <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Esparza Gomez German Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amando Garrido pertierra <\/li>\n<li>agust\u00edn Acevedo barbera (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Teijon rivera (vocal)<\/li>\n<li>Manuel Bravo perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Bascones Ilundain El lp es una enfermedad mucocut\u00e1nea cr\u00f3nica inflamatoria, de etiolog\u00eda desconocida y naturaleza autoinmune [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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