{"id":71725,"date":"2004-10-12T00:00:00","date_gmt":"2004-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicacion-de-sistemas-cromatograficos-y-electroforeticos-a-la-evaluacion-de-propiedades-farmacologicas-de-xenobioticos\/"},"modified":"2004-10-12T00:00:00","modified_gmt":"2004-10-12T00:00:00","slug":"aplicacion-de-sistemas-cromatograficos-y-electroforeticos-a-la-evaluacion-de-propiedades-farmacologicas-de-xenobioticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aplicacion-de-sistemas-cromatograficos-y-electroforeticos-a-la-evaluacion-de-propiedades-farmacologicas-de-xenobioticos\/","title":{"rendered":"Aplicaci\u00f3n de sistemas cromatogr\u00e1ficos y electrofor\u00e9ticos a la evaluaci\u00f3n de propiedades farmacol\u00f3gicas de xenobi\u00f3ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez Pla Juan  Jos\u00e9 <\/strong><\/h2>\n<p>El desarrollo de la qu\u00edmica combinatoria ha hecho posible que un gran n\u00famero de nuevas mol\u00e9culas con potencial actividad terap\u00e9utica sean sintetizadas cada d\u00eda en los laboratorios farmac\u00e9uticos. Sin embargo, solo unas pocas de estas mol\u00e9culas pueden llegar a comercializarse como f\u00e1rmacos dado que la inmensa mayor\u00eda no cumplen los requisitos necesarios. Este bajo \u00edndice de \u00e9xito de los nuevos candidatos hace necesaria una racionalizaci\u00f3n en el desarrollo de nuevos f\u00e1rmacos. De esta manera se reducen los costes, se aceleran las etapas pre-cl\u00ednicas de evaluaci\u00f3n de los nuevos candidatos y se minimiza el uso de animales de experimentaci\u00f3n, acomod\u00e1ndose as\u00ed la industria farmac\u00e9utica a las implicaciones \u00e9ticas que conllevan los ensayos in vivo.  diferentes m\u00e9todos te\u00f3ricos y experimentales han demostrado ser \u00fatiles para obtener una primera estimaci\u00f3n semi-cuantitativa r\u00e1pida (\u00abscreening\u00bb) de las propiedades farmacol\u00f3gicas de inter\u00e9s de las mol\u00e9culas bajo estudio. estas estimaciones constituyen un valioso punto de partida en la estimaci\u00f3n de las propiedades farmacol\u00f3gicas de xenobi\u00f3ticos ya que permiten excluir en las primeras etapas del desarrollo de nuevos f\u00e1rmacos aquellas mol\u00e9culas cuyas propiedades no sean las deseadas.  esta tesis presenta aplicaciones de diferentes sistemas cromatogr\u00e1ficos y electrofor\u00e9ticos a la descripci\u00f3n y predicci\u00f3n de diferentes propiedades farmacol\u00f3gicas de xenobi\u00f3ticos. En concreto, se estudia la aplicabilidad de la cromatograf\u00eda micelar de bio-reparto (cmb), la cromatograf\u00eda de liposomas inmovilizados (ilc) y la electroforesis capilar (ce) como t\u00e9cnicas in vitro para la descripci\u00f3n y predicci\u00f3n de diversas propiedades farmacocin\u00e9ticas y farmacodin\u00e1micas, tales como absorci\u00f3n oral, uni\u00f3n a prote\u00ednas plasm\u00e1ticas, volumen de distribuci\u00f3n, aclaramiento, eliminaci\u00f3n renal, permeabilidad cut\u00e1nea y concentraciones plasm\u00e1ticas terap\u00e9uticas y t\u00f3xicas, de un conjunto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaci\u00f3n de sistemas cromatogr\u00e1ficos y electrofor\u00e9ticos a la evaluaci\u00f3n de propiedades farmacol\u00f3gicas de xenobi\u00f3ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaci\u00f3n de sistemas cromatogr\u00e1ficos y electrofor\u00e9ticos a la evaluaci\u00f3n de propiedades farmacol\u00f3gicas de xenobi\u00f3ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez Pla Juan  Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jos\u00e9 Medina Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  De la guardia cirujeda Miguel <\/li>\n<li>t.d. Cronin mark (vocal)<\/li>\n<li>marina Herraez dominguez (vocal)<\/li>\n<li>alejandro Cifuentes gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez Pla Juan Jos\u00e9 El desarrollo de la qu\u00edmica combinatoria ha hecho posible que un gran n\u00famero [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[679,1595,339,9,2445,957,17,18],"tags":[62650,156199,136374,3310,156198,127340],"class_list":["post-71725","post","type-post","status-publish","format-standard","hentry","category-analisis-bioquimico","category-analisis-cromatografico","category-analisis-de-farmacos","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-quimica","category-quimica-analitica","tag-alejandro-cifuentes-gallego","tag-de-la-guardia-cirujeda-miguel","tag-maria-jose-medina-hernandez","tag-marina-herraez-dominguez","tag-Martinez-pla-juan-jose","tag-t-d-cronin-mark"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71725"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71725\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}