{"id":71738,"date":"2004-10-12T00:00:00","date_gmt":"2004-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-inmunogenetica-hla-de-clase-ii-y-de-los-factores-pronosticos-en-la-artritis-reumatoide\/"},"modified":"2004-10-12T00:00:00","modified_gmt":"2004-10-12T00:00:00","slug":"estudio-de-la-inmunogenetica-hla-de-clase-ii-y-de-los-factores-pronosticos-en-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/reumatologia\/estudio-de-la-inmunogenetica-hla-de-clase-ii-y-de-los-factores-pronosticos-en-la-artritis-reumatoide\/","title":{"rendered":"Estudio de la inmunogen\u00e9tica hla de clase ii y de los factores pron\u00f3sticos en la artritis reumatoide"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonia \u00e1ngela Pecond\u00f3n Espa\u00f1ol <\/strong><\/h2>\n<p>Objetivos     1,- conocer alelos y genotipos de hla de clase ii que se asocian con la susceptibilidad para tener ar en los pacientes de nuestra \u00e1rea geogr\u00e1fica.     2,- estudiar si existe asociaci\u00f3n entre presencia de determinados alelos\/genotipos drb1 y algunas caracter\u00edsticas cl\u00ednica de la ar (factor reumatoide, erosiones, haq, sexo).     3,- investigar si los alelos hla-drb1 tienen valor pron\u00f3stico de desenlace funcional y da\u00f1o radiol\u00f3gico.     4,- determinar qu\u00e9 variables no gen\u00e9ticas recogidas al comienzo de la enfermedad tienen valor pronostico de desenlace funcional y da\u00f1o radiol\u00f3gico.  m\u00e9todo     los pacientes fueron reclutados en consultas externas de reumatolog\u00eda del hospital universitario miguel servet de zaragoza. Criterios de inclusi\u00f3n fueron cumplir los criterios de clasificaci\u00f3n de la acr para ar.  Los controles fueron individuos sanos de ambos sexos donantes de m\u00e9dula \u00f3sea. Este trabajo consta de:     1,- un estudio caso-control para investigar susceptiblidad gen\u00e9tica, con 141 pacientes y 166 controles.     2,- una serie de 141 casos para estudiar caracter\u00edsticas cl\u00ednicas y su posible asociaci\u00f3n con el hla de clase ii.     3,- un estudio longitudinal para investigar posibles factores pronostico, donde se incluyeron 83 pacientes con ar a lo que se pudo hacer seguimiento prospectivo o retrospectivo.     las variables recogidas en los pacientes hacen referencia a datos demogr\u00e1ficos, caracter\u00edsticas, cl\u00ednica, medidas de actividad inflamatoria haq, \u00edndice de larsen, determinaci\u00f3n de alelos hla drb1 por t\u00e9cnicas de baja resoluci\u00f3n entre otras. Los datos recogidos en los controles fueron los alelos hla y el sexo. El estudio estad\u00edstico llevado a cabo consta de resultados descriptivos e inferenciales.  resultados y conclusiones     en nuestra \u00e1rea geogr\u00e1fica los alelos asociados a susceptiblidad, para sufrir artritis reumatoide han sido drb1*01 y drb1*04. No se han detectado que los alelos de susceptibi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la inmunogen\u00e9tica hla de clase ii y de los factores pron\u00f3sticos en la artritis reumatoide<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la inmunogen\u00e9tica hla de clase ii y de los factores pron\u00f3sticos en la artritis reumatoide <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonia \u00e1ngela Pecond\u00f3n Espa\u00f1ol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Larrad Mur<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Gia g\u00f3mez <\/li>\n<li>loreto Carmona ortells (vocal)<\/li>\n<li> Arribas lorente Jos\u00e9 Luis (vocal)<\/li>\n<li>Fernando Civeira murillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonia \u00e1ngela Pecond\u00f3n Espa\u00f1ol Objetivos 1,- conocer alelos y genotipos de hla de clase ii que se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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