{"id":71783,"date":"2018-03-09T23:16:29","date_gmt":"2018-03-09T23:16:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/moleculas-de-adhesion-endotelial-nuevas-dianas-terapeuticas-en-la-enfermedad-inflamatoria-intestinal\/"},"modified":"2018-03-09T23:16:29","modified_gmt":"2018-03-09T23:16:29","slug":"moleculas-de-adhesion-endotelial-nuevas-dianas-terapeuticas-en-la-enfermedad-inflamatoria-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/moleculas-de-adhesion-endotelial-nuevas-dianas-terapeuticas-en-la-enfermedad-inflamatoria-intestinal\/","title":{"rendered":"Mol\u00e9culas de adhesi\u00f3n endotelial: nuevas dianas terap\u00e9uticas en la enfermedad inflamatoria intestinal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Soriano Izquierdo <\/strong><\/h2>\n<p>Introducci\u00f3n: el tratamiento de la enfermedad inflamatoria intestinal se ha basado en el uso de aminosalicilatos, corticoides e inmunosupresores, que ayudan a controlar los brotes de la enfermedad, aunque no consiguen su  curaci\u00f3n. El bloqueo de las mol\u00e9culas de adhesi\u00f3n endotelial, que permiten el reclutamiento de leucocitos desde el lecho vascular hacia el \u00e1rea inflamada, podria ser una diana terap\u00e9utica \u00fatil en esta enfermedad.  objetivos: 1. Determinar el valor de las mol\u00e9culas de adhesi\u00f3n endotelial como nuevas dianas terap\u00e9uticas en la enfermedad inflamatoria del intestino. 2. Evaluar el posible valor terap\u00e9utico de su modulaci\u00f3n con anticuerpos  monoclonales bloqueantes de las mol\u00e9culas de adhesi\u00f3n endotelial, p\u00e9ptidos tr\u00e9bol y ciclosporina a. Material y m\u00e9todos: el modelo experimental utilizado ha sido el de la colitis inducida por dss en el rat\u00f3n, que remeda  la colitis ulcerosa en humanos. Para cuantificar la expresi\u00f3n in vivo de las mol\u00e9culas de adhesi\u00f3n endotelial se ha recurrido a la t\u00e9cnica del doble anticuerpo marcado y para evaluar su expresi\u00f3n in vitro, a los cultivos primarios de c\u00e9lulas endoteliales de vena de cord\u00f3n umbilical humano. Asimismo, para analizar las interacciones leucocito-endotelio en la v\u00e9nulas del colon se ha utilizado la microscopia intravital de fluorescencia.  resultados y conclusiones: 1. En la colitis experimental inducida por dss existe un aumento en la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n endotelial icam-1, vcam-1 y madcam-1 y de las interacciones leucocito-endotelio (rodamiento y adhesi\u00f3n) en las v\u00e9nulas postcapilares del colon. 2. Vcam-1 esla principal mol\u00e9cula responsable del incremento de la adhesi\u00f3n leucocitaria al endotelio y juega un papel fundamental en la fisiopatolog\u00eda de la enfermedad inflamatoria intestinal experimental. 3. El inmunobloqueo sostenido de vcam-1 tiene efecto terap\u00e9utico, ya que mejora el curso de la colitis. En cambio, la inmunoneu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mol\u00e9culas de adhesi\u00f3n endotelial: nuevas dianas terap\u00e9uticas en la enfermedad inflamatoria intestinal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mol\u00e9culas de adhesi\u00f3n endotelial: nuevas dianas terap\u00e9uticas en la enfermedad inflamatoria intestinal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Soriano Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juli\u00e1n Pan\u00e9s D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jaume Bosch genover <\/li>\n<li>Elena Ricart gomez (vocal)<\/li>\n<li>daniel Closa autet (vocal)<\/li>\n<li>montserrat Andreu garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Soriano Izquierdo Introducci\u00f3n: el tratamiento de la enfermedad inflamatoria intestinal se ha basado en el uso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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