{"id":71789,"date":"2018-03-09T23:16:29","date_gmt":"2018-03-09T23:16:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-de-invasion-en-cancer-colorrectal-con-y-sin-inestabilidad-en-microsatelites-importancia-cla%c2%adnica-de-las-metaloproteasas\/"},"modified":"2018-03-09T23:16:29","modified_gmt":"2018-03-09T23:16:29","slug":"mecanismos-moleculares-de-invasion-en-cancer-colorrectal-con-y-sin-inestabilidad-en-microsatelites-importancia-cla%c2%adnica-de-las-metaloproteasas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-moleculares-de-invasion-en-cancer-colorrectal-con-y-sin-inestabilidad-en-microsatelites-importancia-cla%c2%adnica-de-las-metaloproteasas\/","title":{"rendered":"Mecanismos moleculares de invasi\u00f3n en c\u00e1ncer colorrectal con y sin inestabilidad en microsat\u00e9lites. importancia cl\u00ednica de las metaloproteasas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Mor\u00e1n Mill\u00e1n <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal es uno de los principales problemas de salud de la poblaci\u00f3n occidental, puesto que supone la segunda neoplasia m\u00e1s com\u00fan en los paises desarrollados. La mayor parte de los casos de c\u00e1ncer colorrectal (ccr)  aparece de forma espor\u00e1dica y se desarrolla a trav\u00e9s de dos vias carcinog\u00e9nicas con caracterlsticas moleculares y clinicas diferentes. De este modo, la vla supresora, mayoritaria en los tumores espor\u00e1dicos se caracte\u00f1za por la presencia de mutaciones en oncogenes y genes supresores, como ras y p53, y por tener un mal pron\u00f3stico clinico. Estas mutaciones est\u00e1n casi ausentes en la vla del fenotipo mutador, que, en cambio, presenta inestabilidad en secuencias microsat\u00e9lite. Los tumores que se desarrollan a trav\u00e9s de lavia del fenotipo mutador presentan menor agresividad y, por tanto, un mejor pron\u00f3stico cllnico. Los mecanismos moleculares que explicarlan este mejor pron\u00f3stico son; por el momento, desconocidos. En un intento por buscar esta explicaci\u00f3n molecular, hemos estudiado diversas metaloproteasas (mmp) en relaci\u00f3n con este tipo de tumores. Las metaloproteasas son mol\u00e9culas que tienen  funciones muy diversas, entre las que destaca su papel en la facilitaci6n de la invasi\u00f3n tumora!. Son mol\u00e9culas que se han asociado con un mal pron\u00f3stico.  en esta tesis demostramos que la estromelisina-1 \u00f3 mmp-3, es diana del fenotipo mutador. En su regi\u00f3n promotora cuenta con una regi\u00f3n microsat\u00e9lite que se encuentra alterada en los tumores que se desarrollan a trav\u00e9s del fenotipo mutador. Esta alteraci\u00f3n provoca una disminuci\u00f3n de su expresi\u00f3n, lo cual impide que lleve a cabo sus funciones de una manera plenamente efectiva. Entre estas funciones destaca su papel como activador de la mmp-9, metaloproteasa asociada a progresi\u00f3n tumoral y desc\u00f1ta como mol\u00e9cula de mal pron\u00f3stico en c\u00e1ncer colorrecta!. Por otra parte, la mmp-3 es capaz de proteolizar a la mol\u00e9cula de adhesi\u00f3n e-cadhe\u00f1na. El f<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares de invasi\u00f3n en c\u00e1ncer colorrectal con y sin inestabilidad en microsat\u00e9lites. importancia cl\u00ednica de las metaloproteasas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares de invasi\u00f3n en c\u00e1ncer colorrectal con y sin inestabilidad en microsat\u00e9lites. importancia cl\u00ednica de las metaloproteasas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Mor\u00e1n Mill\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Roman Benito De Las Heras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo D\u00edaz-rubio Garc\u00eda <\/li>\n<li>trinidad Caldes llopis (vocal)<\/li>\n<li>Miguel Quintanilla avila (vocal)<\/li>\n<li>Alberto Martin pendas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Mor\u00e1n Mill\u00e1n El c\u00e1ncer colorrectal es uno de los principales problemas de salud de la poblaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[9225,156321,20991,5427,7260,66661],"class_list":["post-71789","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alberto-martin-pendas","tag-alberto-moran-millan","tag-eduardo-diaz-rubio-garcia","tag-manuel-roman-benito-de-las-heras","tag-miguel-quintanilla-avila","tag-trinidad-caldes-llopis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71789"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71789\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}