{"id":71825,"date":"2018-03-09T23:16:34","date_gmt":"2018-03-09T23:16:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-principios-activos-de-allium-sativum-l\/"},"modified":"2018-03-09T23:16:34","modified_gmt":"2018-03-09T23:16:34","slug":"estudio-farmacologico-de-principios-activos-de-allium-sativum-l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-principios-activos-de-allium-sativum-l\/","title":{"rendered":"Estudio farmacol\u00f3gico de principios activos de allium sativum l."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Matilde Y\u00e1\u00f1ez Jato <\/strong><\/h2>\n<p>El ajo (allium sativum l.) Es una de las plantas medicinales m\u00e1s conocidas y estudiadas. Su efecto sobre el sistema cardiovascular es, quiz\u00e1s, uno de los m\u00e1s extensamente documentados en la bibliograf\u00eda cient\u00edfica. Aunque su poder terap\u00e9utico parece evidente, su mecanismo de acci\u00f3n no se conoce con exactitud y son numerosos los estudios que aparecen continuamente tratando de clarificarlo.  los resultados de los estudios son poco homog\u00e9neos y a veces contradictorios debido a las distintas metodolog\u00edas empleadas y a la variabilidad en las condiciones experimentales. Gran parte de las diferencias observadas se deben tambi\u00e9n a la gran diversidad de preparados de ajo utilizados, en los que var\u00eda significativamente la concentraci\u00f3n de los compuestos activos. por ello, en este trabajo se eval\u00faan de forma independiente los efectos y los mecanismos de acci\u00f3n sobre las plaquetas sangu\u00edneas y las c\u00e9lulas musculares lisas vasculares de cuatro compuestos caracter\u00edsticos de esta planta que, aunque no est\u00e1n presentes en la forma natural, se forman r\u00e1pidamente tras su trituraci\u00f3n: alicina, ajoene, disulfuro de d\u00edalilo y disulfuro  de dipropilo.  la alicina y el ajoene, en un rango de concentraciones 1-25 um,y el disulfuro de dialilo y el disulfuro de dipropilo en un rango 50-500 1umbloquean por completo la acci\u00f3n agregante del col\u00e1geno, mientras que muestran un efecto inhibidor dependiente de la concentraci\u00f3n frente a trombina o ionomicina.  cuando se utiliza una concentraci\u00f3n 500 umde disulfuro de dialilo se produce un aumento importante de la concentraci\u00f3n citos\u00f3lica de calcio, que provoca la formaci\u00f3n de microves\u00edculas plaquetarias.  con una concentraci\u00f3n 100 umde disulfuro de dipropilo se provoca una activaci\u00f3n de la fosfolipasa c, que conduce a una activaci\u00f3n de las  plaquetas con resultado de agregaci\u00f3n.  al evaluar el efecto de la alicina y el ajoene sobre los distintos puntos del proceso de activaci\u00f3n plaqu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacol\u00f3gico de principios activos de allium sativum l.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacol\u00f3gico de principios activos de allium sativum l. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Matilde Y\u00e1\u00f1ez Jato <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Reyes Laguna Fracia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Orallo cambeiro <\/li>\n<li>rosal\u00eda Carr\u00f3n de la calle (vocal)<\/li>\n<li>diego m. Cortes mart\u00ednez (vocal)<\/li>\n<li>eugenio Uriarte villares (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Matilde Y\u00e1\u00f1ez Jato El ajo (allium sativum l.) Es una de las plantas medicinales m\u00e1s conocidas y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,2444,977],"tags":[2514,3182,6260,156392,156393,39332],"class_list":["post-71825","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-naturales","category-santiago-de-compostela","tag-diego-m-cortes-Martinez","tag-eugenio-uriarte-villares","tag-francisco-orallo-cambeiro","tag-matilde-yanez-jato","tag-reyes-laguna-fracia","tag-rosalia-carron-de-la-calle"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=71825"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/71825\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=71825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=71825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=71825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}