{"id":71832,"date":"2018-03-09T23:16:34","date_gmt":"2018-03-09T23:16:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aislamiento-estudio-actividad-biologa%c2%adca-y-sitensis-biologa%c2%adca-y-sintesis-de-metabolitos-de-origen-vegetal\/"},"modified":"2018-03-09T23:16:34","modified_gmt":"2018-03-09T23:16:34","slug":"aislamiento-estudio-actividad-biologa%c2%adca-y-sitensis-biologa%c2%adca-y-sintesis-de-metabolitos-de-origen-vegetal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/aislamiento-estudio-actividad-biologa%c2%adca-y-sitensis-biologa%c2%adca-y-sintesis-de-metabolitos-de-origen-vegetal\/","title":{"rendered":"Aislamiento estudio, actividad biolog\u00edca y sitensis biolog\u00edca y sintesis de metabolitos de origen vegetal."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Boluda Cabrera Carlos Jose <\/strong><\/h2>\n<p>Se ha realizado un revisi\u00f3n bibliogr\u00e1fico de los lignanos que incluye sus tipos, metabolismo, funciones fisiol\u00f3gicas y actividades biol\u00f3gicas. Se han aislado 9 compuestos conocidos de bupleurun handiense y 5 de justicia hyssopifolia, ambas end\u00e9micas de canarias. Tambi\u00e9n seha aislado y caracterizado un nuevo lignado de justicia hyssopifolia, al que hemos denominado justicidona y que hasta la fecha es el \u00fanico que posee adem\u00e1s un sistema quin\u00f3nico. se han llevado a cabo varias aproximaciones a las s\u00edntesis total de la justicidona que han puesto de manifiesto la existencia de ciertas dificultades a la hora de emplear los m\u00e9todos est\u00e1ndar de s\u00edntesis para lignanos arilnaftel\u00e9nicos. se ha dise\u00f1ado una estrategia sint\u00e9tica para resolver los problemas encontrados que ha permitido llevar a cabo la s\u00edntesis total de la justificadora en 8 etapas, mediante una secuencia lineal de reaccines bien conocidad. Se ha llevado a cabo un experimento con el objeto de estudiar la dificultad encontrada en la ciclaci\u00f3n de uno de los presursores sint\u00e9tivos de la justicidona. este experimento permiti\u00f3 adem\u00e1s llevar a cabo la s\u00edntesis total de la justicidina e en 6 etapas. Por otra parte, seha llevado a cabo la semis\u00edntesis de la justicidona y de otro lignano que tambi\u00e9n participa de un sistemas quin\u00f3nico. Se ha llevado a cabo la acetilaci\u00f3n enzim\u00e1tica regioselectiva de secoiridoides aislados de jadminum odoratisimun empleando la lipasa de candinda antarctica y se han obtenido de este modo nuevos productos dif\u00edciloes de sintetizar por los m\u00e9todos sinteticos convencionales. Finalmente, se evalu\u00f3 la actividad antilesihamni y citotoxica  de los compuestos naturales y sint\u00e9ticos obtenidos. Justicidona y alguno de sus precursores sint\u00e9ticos mostraron tener actividad citot\u00f3xica y antileshmania.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aislamiento estudio, actividad biolog\u00edca y sitensis biolog\u00edca y sintesis de metabolitos de origen vegetal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aislamiento estudio, actividad biolog\u00edca y sitensis biolog\u00edca y sintesis de metabolitos de origen vegetal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Boluda Cabrera Carlos Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Hermelo Lopez Dorta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: angel Gutierrez ravelo <\/li>\n<li>Mar\u00eda  Jes\u00fas Ayuso gonzalez (vocal)<\/li>\n<li> Sivero exposito Jos\u00e9 Manuel (vocal)<\/li>\n<li>Jorge Triana mendez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Boluda Cabrera Carlos Jose Se ha realizado un revisi\u00f3n bibliogr\u00e1fico de los lignanos que incluye sus tipos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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