{"id":71914,"date":"2018-03-09T23:16:38","date_gmt":"2018-03-09T23:16:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-asociacion-de-dexmedetomidina-y-midazolam-sobre-la-concentracion-alveolar-ma%c2%adnima-de-halotano-e-isoflurano-en-ratas\/"},"modified":"2018-03-09T23:16:38","modified_gmt":"2018-03-09T23:16:38","slug":"efecto-de-la-asociacion-de-dexmedetomidina-y-midazolam-sobre-la-concentracion-alveolar-ma%c2%adnima-de-halotano-e-isoflurano-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/efecto-de-la-asociacion-de-dexmedetomidina-y-midazolam-sobre-la-concentracion-alveolar-ma%c2%adnima-de-halotano-e-isoflurano-en-ratas\/","title":{"rendered":"Efecto de la asociaci\u00f3n de dexmedetomidina y midazolam sobre la concentraci\u00f3n alveolar m\u00ednima de halotano e isoflurano en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Rioja Garc\u00eda <\/strong><\/h2>\n<p>La dexmedetomidina, un agente agonista de los receptores adren\u00e9rgicos alfa2, y el midazolam, una benzodiacepina, presentan una interacci\u00f3n sin\u00e9rgica en los efectos sedante y analg\u00e9sico. El prop\u00f3sito del presente estudio consisti\u00f3 en evaluar la interacci\u00f3n que tiene lugar entre estos dos f\u00e1rmacos en el efecto  de reducci\u00f3n de la concentraci\u00f3n alveolar m\u00ednima (cam) de halotano y de isoflurano. Para la realizaci\u00f3n de este trabajo se utilizaron un total de 56 ratas wistar que fueron distribuidas de manera aleatoria en 8 grupos (n=7 \u00f3 8), cuatro grupos de halotano (hal) y cuatro grupos de isoflurano (iso). Los grupos denominados sal+hal y sal+iso recibieron soluci\u00f3n salina fisiol\u00f3gica, los grupos sal+mid+hal y sal+mid+iso recibieron un bolo intravenoso de midazolam (1 mg\/kg), los grupos dex+sal+hal y dex+sal+iso recibieron una infusi\u00f3n intravenosa continua de dexmedetomidina (0.25 ug\/kg\/min)y  los grupos dex+mid+hal y dex+mid+iso recibieron tanto la infusi\u00f3n de dexmedetomidina (0.25 ug\/kg\/min)como el bolo de midazolam (1 mg\/kg). Durante todo el periodo anest\u00e9sico se monitorizaron los par\u00e1metros cardiovasculares y respiratorios, as\u00ed como la temperatura corporal, de todos los animales  de estudio. Al final de cada experimento se realiz\u00f3 una gasometr\u00eda arterial. la determinaci\u00f3n de la cam se realiz\u00f3 mediante la aplicaci\u00f3n de un est\u00edmulo doloroso supram\u00e1ximo, consistente en el clampalede la base de la cola durante 60 segundos. Los datos fueron analizados estad\u00edsticamente mediante un an\u00e1lisis de varianza (anova) de una v\u00eda y un an\u00e1lisis de tukey-kramer para comparaciones m\u00faltiples, consider\u00e1ndose un nivel de significaci\u00f3n estad\u00edstica de p mayor 0.01. Los valores de cam de halotano y de isoflurano, ajustados a la presi\u00f3n barom\u00e9trica al nivel del mar y expresados como la media :t la desviaci\u00f3n t\u00edpica, fueron 1.31 + &#8211; 0.1% para el hal y 1.46 +- 0.05% para el iso en los grupos control (sal+hal y sal+iso respecti<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la asociaci\u00f3n de dexmedetomidina y midazolam sobre la concentraci\u00f3n alveolar m\u00ednima de halotano e isoflurano en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la asociaci\u00f3n de dexmedetomidina y midazolam sobre la concentraci\u00f3n alveolar m\u00ednima de halotano e isoflurano en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Rioja Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Tendillo Cortijo Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan a Mar\u00eda Flores landeira <\/li>\n<li> Belda nacher Francisco Javier (vocal)<\/li>\n<li> San Andr\u00e9s larrea Manuel (vocal)<\/li>\n<li>Mar\u00eda sol Carrasco jim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Rioja Garc\u00eda La dexmedetomidina, un agente agonista de los receptores adren\u00e9rgicos alfa2, y el midazolam, una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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