{"id":71965,"date":"2018-03-09T23:16:42","date_gmt":"2018-03-09T23:16:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modular-approach-to-the-synthesis-of-ipcs-inhibitors-a-antifungal-agents\/"},"modified":"2018-03-09T23:16:42","modified_gmt":"2018-03-09T23:16:42","slug":"modular-approach-to-the-synthesis-of-ipcs-inhibitors-a-antifungal-agents","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/modular-approach-to-the-synthesis-of-ipcs-inhibitors-a-antifungal-agents\/","title":{"rendered":"Modular approach to the synthesis of ipcs inhibitors a antifungal agents"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Serrano Navarro <\/strong><\/h2>\n<p>El n\u00famero de pacientes con patolog\u00edas asociadas con hongos ha crecido de forma alarmente en los \u00faltimos a\u00f1os. Este trabajo presta especial atenci\u00f3n a la preparaci\u00f3n de mol\u00e9culas que puedan hacer frente a la micosis sist\u00e9micas dado que provocan un elevado grado de mortalidad y su incidencia ha ido creciendo de modo significativo.  en base a la limitada eficacia de los f\u00e1rmacos disponibles en la actualidad este trabajo aborda la s\u00edntesis de potenciales agentes antif\u00fangicos en basados en la inhibici\u00f3n del metabolismo de esfingol\u00edpidos en hongos, concretamente del enzima inositol fosfoceramida sintasa.  con este objetivo, se han preparado como cabezas de serie, an\u00e1logos de inositol para su posterior derivatizaci\u00f3n mediante t\u00e9cnicas combinatorias en disoluci\u00f3n. Una aproximaci\u00f3n alternativa nos ha llevado a la s\u00edntesis de an\u00e1logos de kafrefungina, uno de los pocos inhibidores conocidos frente ha este enzima.  adem\u00e1s, se han realizado estudios mecan\u00edsticos de la apertura de ep\u00f3xidos en presencia de liclo4 y yb(otf)3 mediante t\u00e9cnicas de rmn y c\u00e1lculos ab initio. Finalmente, la evaluaci\u00f3n preliminar de la actividad antif\u00fangica de los compuestos sintetizados ha permitido obtener informaci\u00f3n acerca de su aplicabilidad en este campo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modular approach to the synthesis of ipcs inhibitors a antifungal agents<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modular approach to the synthesis of ipcs inhibitors a antifungal agents <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Serrano Navarro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Delgado Cirilo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Camps diez <\/li>\n<li>stephen Lindell (vocal)<\/li>\n<li>diego Mu\u00f1oz-torrero lopez-ibarra (vocal)<\/li>\n<li>Andr\u00e9s Fernandez garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Serrano Navarro El n\u00famero de pacientes con patolog\u00edas asociadas con hongos ha crecido de forma alarmente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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