{"id":71976,"date":"2018-03-09T23:16:42","date_gmt":"2018-03-09T23:16:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-protector-de-los-flavonoides-en-un-modelo-de-inflamacion-en-hepatocitos-aislados\/"},"modified":"2018-03-09T23:16:42","modified_gmt":"2018-03-09T23:16:42","slug":"papel-protector-de-los-flavonoides-en-un-modelo-de-inflamacion-en-hepatocitos-aislados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-protector-de-los-flavonoides-en-un-modelo-de-inflamacion-en-hepatocitos-aislados\/","title":{"rendered":"Papel protector de los flavonoides en un modelo de inflamaci\u00f3n en hepatocitos aislados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Martinez Florez <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os se est\u00e1 dando una importancia creciente al uso de productos naturales con capacidad antioxidante por sus probados efectos beneficiosos para la salud. Los flavonoides han demostrado un alto potencial terap\u00e9utico en diversas patolog\u00edas y, asimismo, desempe\u00f1an una acci\u00f3n protectora en procesos inflamatorios.  el h\u00edgado es un \u00f3rgano que, por su funci\u00f3n fisiol\u00f3gica, est\u00e1 sometido a un alto grado de estr\u00e9s oxidativo, ya que es el principal \u00f3rgano metab\u00f3lico del organismo. Las defensas antioxidantes hep\u00e1ticas pueden verse alteradas en determinadas situaciones fisiol\u00f3gicas o patol\u00f3gicas que cursan con un alto grado de estr\u00e9s oxidativo, dificultando as\u00ed la funci\u00f3n hep\u00e1tica y facilitando la evoluci\u00f3n de hepatopat\u00edas.  por ello, el objetivo de la tesis doctoral fue evaluar los potenciales efectos positivos del flavonoide quercitina sobre las alteraciones producidas en un modelo experimental de inglamaci\u00f3n hep\u00e1tica inducido por el tratamiento con la citoquina interleucina-1 beta (il-1b) en hepatocitos aislados de rata, con el fin de dilucidar en lo posible los mecanismos implicados.  el flavonoide utilizado en este trabajo, el polihidroxiflavonol quercitina, presenta un claro efecto protector frente a las alteraciones de car\u00e1cter oxidativo producidas por la administraci\u00f3n de la citoquina proinflamatoria interleucina 1 beta en hepatocitos aislados de rata, ya que reduce la formaci\u00f3n de especies reactivas de ox\u00edgeno y nitr\u00f3geno, incrementa la concentraci\u00f3n del trip\u00e9ptido glutati\u00f3n, e inhibe en gran medida las alteraciones de la expresi\u00f3n g\u00e9nica de la enzima antioxidante super\u00f3xido dismutasa mitocondrial.  el tratamiento de los hepatocitos con el flavonoide quercitina contrarresta el incremento en la producci\u00f3n de \u00f3xido n\u00edtrico inducida por la administraci\u00f3n de la interleucina 1 beta, mediante una reducci\u00f3n de la expresi\u00f3n g\u00e9nica de la enzima \u00f3xido n\u00edtrico sintetasa y de la liberaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel protector de los flavonoides en un modelo de inflamaci\u00f3n en hepatocitos aislados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel protector de los flavonoides en un modelo de inflamaci\u00f3n en hepatocitos aislados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Martinez Florez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jes\u00fas Tu\u00f1\u00f3n Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alejandro Esteller  perez <\/li>\n<li>gin\u00e9s Salido ruiz (vocal)<\/li>\n<li>Javier Gonz\u00e1lez gallego (vocal)<\/li>\n<li>Jes\u00fas Culebras fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Martinez Florez En los \u00faltimos a\u00f1os se est\u00e1 dando una importancia creciente al uso de productos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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