{"id":71994,"date":"2018-03-09T23:16:42","date_gmt":"2018-03-09T23:16:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-del-melanoma-trasplantable-modelos-experimentales-in-vitro-e-in-vivo\/"},"modified":"2018-03-09T23:16:42","modified_gmt":"2018-03-09T23:16:42","slug":"tratamiento-del-melanoma-trasplantable-modelos-experimentales-in-vitro-e-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-del-melanoma-trasplantable-modelos-experimentales-in-vitro-e-in-vivo\/","title":{"rendered":"Tratamiento del melanoma trasplantable modelos experimentales in vitro e in vivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Pascual Carpe <\/strong><\/h2>\n<p>Hemos desarrollado dos modelos experimentales  \u00abin vitro\u00bb e \u00abin vivo\u00bb de tratamiento de melanomas murinos. En el modelo \u00abin vitro\u00bb estudiamos los efectos citot\u00f3xicos y antiproliferativos de los tres agentes  ensayados melfal\u00e1n, interfer\u00f3n alfa y lymphomyosot sobre la l\u00ednea de melanoma murino b16f10.  el melfal\u00e1n demostr\u00f3 los mayores efectos citot\u00f3xicos y antiproliferativos, con una curva dosis-respuesta, seguido del interfer\u00f3n alfa, aunque este s\u00f3lo con las concentraciones m\u00e1s altas, mientras que el lymphomyosot no present\u00f3 acci\u00f3n citot\u00f3xica ni antiproliferativa a ninguna de las concentraciones utilizadas.  el modelo \u00abin vivo\u00bb, fue desarrollado mediante la inoculaci\u00f3n subcut\u00e1nea de melanocitos de las l\u00edneas b16f10 y b16 en la regi\u00f3n inguinal izquierda a ratones de la cepa c57bl\/6j. Nuestro modelo ha demostrado ser eficaz ya que los tumores  prendieron en todos los animales implantados y a todas las concentraciones de c\u00e9lulas inoculadas ( 1&#215;106, 5&#215;105 y 1&#215;105). Investigamos los efectos de los tratamientos, individual y combinado, con interfer\u00f3n alfa y lymphomyosot  a trav\u00e9s del estudio macrosc\u00f3pico (pesos tumorales), microsc\u00f3pico (caracter\u00edsticas morfol\u00f3gicas, citol\u00f3gicas, necrosis, infiltrados inflamatorios), inmunohistoqu\u00edmico (\u00edndice de proliferaci\u00f3n celular) e inmunol\u00f3gico (poblaciones celulares sanguineas).  en todos los experimentos realizados observamos que los pesos tumorales eran significativamente mayores en el grupo control (animales no tratados) que en los grupos tratados, siendo los de menor peso, significativamente, los tratados con lymphomyosot, as\u00ed como los del interfer\u00f3n alfa y  combinado respectivamente. Lo que demuestra el efecto antitumoral de ambos agentes estudiados. La necrosis tumoral, excepto en el \u00faltimo experimento, era menor en los tratados con lymphomyosot y combinado que con interfer\u00f3n alfa, lo que apoya la ausencia de toxicidad del lymphomyosot y el efecto citot\u00f3xico y ant<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento del melanoma trasplantable modelos experimentales in vitro e in vivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento del melanoma trasplantable modelos experimentales in vitro e in vivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Pascual Carpe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Vicente Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Canteras jordana <\/li>\n<li> Crespo de la rosa  Juan  Carlos (vocal)<\/li>\n<li>Luis Crovetto montoya (vocal)<\/li>\n<li>Jos\u00e9 sebasti\u00e1n Carri\u00f3n Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Pascual Carpe Hemos desarrollado dos modelos experimentales \u00abin vitro\u00bb e \u00abin vivo\u00bb de tratamiento de melanomas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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