{"id":72028,"date":"2018-03-09T23:16:46","date_gmt":"2018-03-09T23:16:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-gen-de-la-renina-en-neoplasias-hematologicas-y-su-papel-en-la-regulacion-de-la-hematopoyesis\/"},"modified":"2018-03-09T23:16:46","modified_gmt":"2018-03-09T23:16:46","slug":"estudio-de-la-expresion-del-gen-de-la-renina-en-neoplasias-hematologicas-y-su-papel-en-la-regulacion-de-la-hematopoyesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-expresion-del-gen-de-la-renina-en-neoplasias-hematologicas-y-su-papel-en-la-regulacion-de-la-hematopoyesis\/","title":{"rendered":"Estudio de la expresi\u00f3n del gen de la renina en neoplasias hematol\u00f3gicas y su papel en la regulaci\u00f3n de la hematopoyesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Iglesia I\u00f1igo Silvia Narcisa De La <\/strong><\/h2>\n<p>Se ha demostrado la existencia de todos los componentes del sistema renina angiotensina en la medula \u00f3sea, aunque no se ha podido establecer su papel en la hematopoyeis.  un 40% de las leucemias mielobl\u00e1sticas agudas (lma) expresan el gen de la renina. El an\u00e1lisis de dicha expresi\u00f3n en los pacientes afectos de lma que carezcan de alteraciones moleculares espec\u00edficas puede ser de utilidad en la detecci\u00f3n de enfermedad m\u00ednima residual, entendida como la persistencia tras el tratamiento de un bajo n\u00famero de blastos no identificables por t\u00e9cnicas citomorfol\u00f3gicas.  objetivos:  1. Analizar la expresi\u00f3n del gen de la renina en pacientes afectos de leucemias agudas, fundamentalmente mielobl\u00e1sticas y relacionar dicha expresi\u00f3n con la evoluci\u00f3n para determinar su valor como marcador de enfermedad m\u00ednima residual (emr).  2. Determinar el papel de la activaci\u00f3n del sistema renina angiotensina en la hematopoyesis.  conclusiones:  1. La expresi\u00f3n del gen de la renina es un marcador \u00fatil de emr dado que se relacion\u00f3 siempre con la existencia de blastos.  2. La pcr a tiempo real es la t\u00e9cnica de elecci\u00f3n para su an\u00e1lisis dado que present\u00f3 mayor sensibilidad que la rt-pcr.  3. Los pacientes afectos de leucemias mielobl\u00e1sticas agudas renina positivos parecen tener un peor pron\u00f3stico con una mayor frecuencia de reca\u00edda, aunque no encontramos una diferencia estad\u00edsticamente significativa en la supervivencia global ni en la supervivencia libre de enfermedad, por lo cual ser\u00eda de inter\u00e9s ampliar el estudio estad\u00edstico.  4. Los inhibidores de la eca producen una disminuci\u00f3n de la proliferaci\u00f3n en la l\u00edneas hl60 y k562, coincidiendo con la disminuci\u00f3n de la expresi\u00f3n de c-myc y no relacionada con la apotosis celular. Dicho efecto parece ser independiente de la angiotensina ii y del acsdkp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n del gen de la renina en neoplasias hematol\u00f3gicas y su papel en la regulaci\u00f3n de la hematopoyesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n del gen de la renina en neoplasias hematol\u00f3gicas y su papel en la regulaci\u00f3n de la hematopoyesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Iglesia I\u00f1igo Silvia Narcisa De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Teresa Molero Labarta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Rodriguez perez <\/li>\n<li>Javier Le\u00f3n serrano (vocal)<\/li>\n<li> Jim\u00e9nez bravo de laguna Santiago (vocal)<\/li>\n<li>montserrat Briz blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Iglesia I\u00f1igo Silvia Narcisa De La Se ha demostrado la existencia de todos los componentes del sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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