{"id":72054,"date":"2018-03-09T23:16:46","date_gmt":"2018-03-09T23:16:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cannabinoides-en-dolor-neuropatico-y-determinacion-farmacologica-de-nuevos-ligandos\/"},"modified":"2018-03-09T23:16:46","modified_gmt":"2018-03-09T23:16:46","slug":"cannabinoides-en-dolor-neuropatico-y-determinacion-farmacologica-de-nuevos-ligandos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cannabinoides-en-dolor-neuropatico-y-determinacion-farmacologica-de-nuevos-ligandos\/","title":{"rendered":"Cannabinoides en dolor neuropatico y determinacion farmacologica de nuevos ligandos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita Suardiaz Garcia <\/strong><\/h2>\n<p>En el primer apartado de este trabajo se ha caracterizado farmacologicamente una nueva serie de compuestos, derivados 1,2,4-triazoles, con actividad cannabinoide. De toda la serie, el compuesto lh1.21 se comporta como un antagonista cannabinoide tanto en estudios in vitro (\u00edleon de cobayo) como in vivo (t\u00e9trada cannabinoide). Este compuesto carece de actividad intr\u00ednseca en los ensayos realizados, siendo, hasta la fecha, el \u00fanico antagonista cannabinoide que no presenta actividad de agonista inverso.  en un segundo grupo de ensayos, se ha estudiado el efecto del agonista cannabinoide win 55212,2 en un nuevo modelo animal de dolor neurop\u00e1tico inducido por la administraci\u00f3n del antineopl\u00e1sico paclitaxel. Los resultados obtenidos demostraron que win (1 mg\/kg) administrado por via intraperitoneal (i.P.) Reduce tanto la hiperalgesia como la alodinia producidas por paclitaxel. adem\u00e1s, esta dosis no indujo las cl\u00e1sicas modificaciones comportamentales producidas por cannabinoides (catalepsia, hipotermia). La dosis de win capaz de producir este efecto es menor que la requerida para obtener los mismos efectos en el modelo de la ligadura del nervio ci\u00e1tico, otro modelo animal de dolor neorop\u00e1tico, puesto que en este \u00faltimo caso se requiere la administraci\u00f3n de 1,5 mg\/kg, i.P. El efecto de win fue antagonizado por el antagonista selectivo sr 141716a, demostrando la participaci\u00f3n del receptor canabinoide cb1. Cuando win se administr\u00f3 por via intraplantar, no se obtuvieron diferencias significativas entre la pata inyectada y la contralateral, lo que sugiere que el efecto el cannabinoide implica mecanismos sist\u00e9micos. De estos resultados se puede concluir que los agonistas cannabinoides podr\u00edan ser una alternativa \u00fatil para el tratamiento del dolor neurop\u00e1tico asociado al uso de paclitaxel.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cannabinoides en dolor neuropatico y determinacion farmacologica de nuevos ligandos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cannabinoides en dolor neuropatico y determinacion farmacologica de nuevos ligandos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita Suardiaz Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rey juan carlos<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Goicoechea Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Martin fontelles <\/li>\n<li>sergio Erill saez (vocal)<\/li>\n<li>Javier Fernandez ruiz (vocal)<\/li>\n<li>Fernando Rodriguez de fonseca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita Suardiaz Garcia En el primer apartado de este trabajo se ha caracterizado farmacologicamente una nueva serie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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