{"id":72084,"date":"2018-03-09T23:16:51","date_gmt":"2018-03-09T23:16:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diferenciacion-adipocitaria-y-factores-reguladores-de-la-biogenesis-mitocondrial-efectos-de-los-farmacos-antiretrovirales\/"},"modified":"2018-03-09T23:16:51","modified_gmt":"2018-03-09T23:16:51","slug":"diferenciacion-adipocitaria-y-factores-reguladores-de-la-biogenesis-mitocondrial-efectos-de-los-farmacos-antiretrovirales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/diferenciacion-adipocitaria-y-factores-reguladores-de-la-biogenesis-mitocondrial-efectos-de-los-farmacos-antiretrovirales\/","title":{"rendered":"Diferenciaci\u00f3n adipocitaria y factores reguladores de la biog\u00e9nesis mitocondrial. efectos  de los f\u00e1rmacos antiretrovirales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Luisa Rodriguez De La Concepci\u00f3n <\/strong><\/h2>\n<p>Los resultados presentados en esta tesis se engloban en tres bloques de estudio: la implicaci\u00f3n del adipocito marr\u00f3n en la lipomatosis inducida por la terapia antiretroviral de elevada actividad (haart), el estudio de nuevos  factores reguladores de la funci\u00f3n mitocondrial en el adipocito marr\u00f3n y el efecto de los f\u00e1rmacos antiretrovirales en adipocitos en cultivo.  el an\u00e1lisis de la expresi\u00f3n del gen marcador del adipocito marr\u00f3n ucp-l en varios lipomas de pacientes infectados con vih y en terapia antiretroviral implica al adipocito marr\u00f3n en la etiopatolog\u00eda de la lipomatosis asociada a la terapia haart.  el estudio de la regulaci\u00f3n de la biog\u00e9nesis mitocondrial a nivel molecular en adipocitos marrones, nos llev\u00f3 a observar que la diferenciaci\u00f3n del adipocito marr\u00f3n va asociada a la inducci\u00f3n de los factores de transcripci\u00f3n  mitocondrial bl y b2 y el co-activador pgc-la, en asociaci\u00f3n con una incrementada biog\u00e9nesis mitocondrial. La expresi\u00f3n g\u00e9nica de estos factores es regulada de forma positiva por agonistas de ppary e insulina. Por el contrario, la noradrenalina reprime la expresi\u00f3n de los factores de transcripci\u00f3n mitocondrlal bl y b2 por mecanismos dependientes  de transcripci\u00f3n e independientes de s\u00edntesis proteica. Ello da lugar a una reducci\u00f3n en la expresi\u00f3n de genes codificados por el genoma mitocondrial como la subunidad ii de la citocromo c oxidasa. Este efecto es dependiente del  grado de diferenciaci\u00f3n del adipocito marr\u00f3n y se ve favorecido por la presencia de activadores de pparyo insulina. La expresi\u00f3n del co-activador pgc-la se induce por noradrenalina, agonistas pparyy agonistas rxr en adipocitos  marrones diferenciados, pero no en preadipocitos. Dichas inducciones se dan por mecanismos independientes de s\u00edntesis proteica. La inducci\u00f3n de pgc-la por la noradrenalina se ve favorecida por la presencia de activadores ppary.  la inducci\u00f3n por agonistas ppary y rxr se bloquea por<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diferenciaci\u00f3n adipocitaria y factores reguladores de la biog\u00e9nesis mitocondrial. efectos  de los f\u00e1rmacos antiretrovirales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diferenciaci\u00f3n adipocitaria y factores reguladores de la biog\u00e9nesis mitocondrial. efectos  de los f\u00e1rmacos antiretrovirales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Luisa Rodriguez De La Concepci\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Villarroya Gombau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mar\u00ed\u00a7al Pastor anglada <\/li>\n<li>\u00f3scar Mir\u00f3  andreu (vocal)<\/li>\n<li>Mar\u00eda  ofelia Mora izaguirre (vocal)<\/li>\n<li>josep Ribalta vives (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Luisa Rodriguez De La Concepci\u00f3n Los resultados presentados en esta tesis se engloban en tres bloques [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,36483,160,35,17],"tags":[34027,70954,156858,156860,12645,156859],"class_list":["post-72084","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-molecular","category-bioquimica","category-ciencias-de-la-vida","category-quimica","tag-francesc-villarroya-gombau","tag-josep-ribalta-vives","tag-m-luisa-rodriguez-de-la-concepcion","tag-maria-ofelia-mora-izaguirre","tag-marial-pastor-anglada","tag-oscar-miro-andreu"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72084"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72084\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72084"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72084"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}