{"id":72108,"date":"2018-03-09T23:16:51","date_gmt":"2018-03-09T23:16:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interraccion-oxido-na%c2%adtrico-calcio-en-la-hiporrespuesta-vascular-de-ratas-cirroticas\/"},"modified":"2018-03-09T23:16:51","modified_gmt":"2018-03-09T23:16:51","slug":"interraccion-oxido-na%c2%adtrico-calcio-en-la-hiporrespuesta-vascular-de-ratas-cirroticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interraccion-oxido-na%c2%adtrico-calcio-en-la-hiporrespuesta-vascular-de-ratas-cirroticas\/","title":{"rendered":"Interracci\u00f3n \u00f3xido n\u00edtrico-calcio en la hiporrespuesta vascular de ratas cirr\u00f3ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Andr\u00e9s Nadal Franciso Javier <\/strong><\/h2>\n<p>Numerosos estudios, in vivo e vitro, confirman la existencia de hiporrespuesta a vasoconstrictores en cirrosis, tanto en humanos como en diferentes especies de animales, tipos de vasos, modelos experimentales de cirrosis y a diferentes agentes vasoconstrictores. En el lecho arterial mesent\u00e9rico perfundido in vitro de ratas se ha demostrado la hiporrespuesta a vasoconstrictores, tanto en cirr\u00f3ticas por ccl4 como en ratas con hipertensi\u00f3n portal por lvp. Tambi\u00e9n se ha comprobado en estas mismas condiciones la hiporrespuesta a kcl, en el modelo de hipertensi\u00f3n portal por lvp (sieber y groszmann, 1992). Pero nunca se ha estudiado este fen\u00f3meno en el lecho arterial mesent\u00e9rico de ratas con ligadura del conductor biliar (lcb), que es el modelo de cirrosis objeto de este trabajo. El determinar la existencia o no de hiporrespuesta en este modelo experimental de cirrosis es muy importante, debido a la gran cantidad de estudios que usan este tipo de cirrosis para todo tipo de investigaciones sobre la fisiopatolog\u00eda de la cirrosis hep\u00e1tica. En pr\u00e1cticamente todos los estudios mencionados se comprob\u00f3 que el no es el principal responsable de la hiporrespuesta usando inhibidores de su s\u00edntesis, por lo que en este trabajo se pretende comprobar tambi\u00e9n el papel del no en estas condiciones (lecho arterial mesent\u00e9rico perfundido in vitro de ratas) y en el modelo de lcb. Adem\u00e1s, como la mayor parte del no se sintetiza en el endotelio, estudiaremos tambi\u00e9n el papel del endotelio. El calcio es el regulador intracelular del mecanismo de la contracci\u00f3n muscular. en las \u00faltimas dos d\u00e9cadas el estudio de la movilizaci\u00f3n del calcio ha avanzado machismo, comprob\u00e1ndose los mecanismos que regulan la concentraci\u00f3n de calcio, tanto por liberaci\u00f3n intracelular del calcio almacenado, como por la entrada de calcio extracelular por distintos canales, operados por voltaje, receptor  o por los almacenes.  en este trabajo hemos analizado los mecanismos q<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interracci\u00f3n \u00f3xido n\u00edtrico-calcio en la hiporrespuesta vascular de ratas cirr\u00f3ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interracci\u00f3n \u00f3xido n\u00edtrico-calcio en la hiporrespuesta vascular de ratas cirr\u00f3ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Andr\u00e9s Nadal Franciso Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Noemi Teresa Marin Atucha<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Hern\u00e1ndez cascales <\/li>\n<li> Garcia borr\u00f3n Jos\u00e9 Carlos (vocal)<\/li>\n<li>Jos\u00e9 f\u00e9lix Vargas palomares (vocal)<\/li>\n<li> Garc\u00eda del r\u00edo cipriano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Nadal Franciso Javier Numerosos estudios, in vivo e vitro, confirman la existencia de hiporrespuesta a vasoconstrictores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,5793,817,491,139,8235],"tags":[156899,4581,36479,3171,3922,146556],"class_list":["post-72108","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-cardiovascular","category-fisiologia-humana","category-gastroenterologia","category-medicina-interna","category-murcia","tag-andres-nadal-franciso-javier","tag-garcia-borron-jose-carlos","tag-garcia-del-rio-cipriano","tag-jesus-hernandez-cascales","tag-jose-felix-vargas-palomares","tag-noemi-teresa-marin-atucha"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72108"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72108\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}