{"id":72143,"date":"2018-03-09T23:16:54","date_gmt":"2018-03-09T23:16:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-resistencia-a-la-muerte-celular-programada-en-cultivos-de-cardiomiocitos-y-fibroblastos-cardiacos-de-rata\/"},"modified":"2018-03-09T23:16:54","modified_gmt":"2018-03-09T23:16:54","slug":"mecanismos-de-resistencia-a-la-muerte-celular-programada-en-cultivos-de-cardiomiocitos-y-fibroblastos-cardiacos-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-de-resistencia-a-la-muerte-celular-programada-en-cultivos-de-cardiomiocitos-y-fibroblastos-cardiacos-de-rata\/","title":{"rendered":"Mecanismos de resistencia a la muerte celular programada en cultivos de cardiomiocitos y fibroblastos cardiacos de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mayorga Mayorga Maritza Elfride <\/strong><\/h2>\n<p>La participaci\u00f3n de la muerte celular programada (apoptosis) en patolog\u00edas cardiovasculares se empez\u00f3 a dilucidar en estudios enfocados en la isquemia mioc\u00e1rdica, el infarto del miocardio y la displasia arritmog\u00e9nica y en modelos animales de isquemia\/reperfusi\u00f3n. A partir de entonces se ha profundizado en la detecci\u00f3n de c\u00e9lulas mioc\u00e1rdicas apopt\u00f3ticas y su distribuci\u00f3n en situaciones de isquemia in vivo en diferentes modelos de experimentaci\u00f3n y en explantes de tejido humano. Sin embargo, la mayor\u00eda de los estudios realizados en humanos sobre la incidencia de la muerte celular programada en el transcurso de patolog\u00edas cardiovasculares, se ha basado en la detecci\u00f3n de las etapas finales de la apoptosis. Dichos trabajos pioneros han puesto en evidencia el potencial papel de la apoptosis como origen o consecuencia de m\u00faltiples patolog\u00edas del sistema cardiovascular aunque las v\u00edas apopt\u00f3ticas que participan a\u00fan est\u00e1n por determinarse.  a partir de diferentes estudios se sabe que la mitocondria juega un papel relevante en el da\u00f1o celular observado en c\u00e9lulas cardiacas bajo situaciones patol\u00f3gicas. De hecho, se ha descrito que los cardiomiocitos pueden presentar una disfunci\u00f3n mitocondrial que comprende una disminuci\u00f3n del potencial de membrana, la apertura del poro de transici\u00f3n mitocondrial y salida de citocromo c en respuesta a diferentes est\u00edmulos de estr\u00e9s como reperfusi\u00f3n postisqu\u00e9mica, estr\u00e9s oxidativo o la estimulaci\u00f3n adren\u00e9rgica. Por otro lado, tambi\u00e9n se ha demostrado que estas c\u00e9lulas presentan una apoptosis interrumpida o incompleta en corazones afectados por cardiomiopat\u00edas y fallo cardiaco sin haberse dilucidado los mecanismos mediadores de esta respuesta. A pesar de la controversia sobre los mecanismos implicados en la resistencia del miocardio a la apoptosis, se d\u00e1 por aceptado que este tipo de muerte forma parte de la muerte celular observada durante isquemia\/reoxigenaci\u00f3n, hipertensi\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de resistencia a la muerte celular programada en cultivos de cardiomiocitos y fibroblastos cardiacos de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de resistencia a la muerte celular programada en cultivos de cardiomiocitos y fibroblastos cardiacos de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mayorga Mayorga Maritza Elfride <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Daniel Sanchis Morales<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ballester rod\u00e9s <\/li>\n<li>Francisco Fern\u00e1ndez aviles (vocal)<\/li>\n<li>Javier Diez Martinez (vocal)<\/li>\n<li>almudena Porras gallo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mayorga Mayorga Maritza Elfride La participaci\u00f3n de la muerte celular programada (apoptosis) en patolog\u00edas cardiovasculares se empez\u00f3 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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