{"id":72156,"date":"2018-03-09T23:16:54","date_gmt":"2018-03-09T23:16:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-transcripcional-del-gen-de-mitofusina-2-en-musculo-esqueletico\/"},"modified":"2018-03-09T23:16:54","modified_gmt":"2018-03-09T23:16:54","slug":"regulacion-transcripcional-del-gen-de-mitofusina-2-en-musculo-esqueletico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/regulacion-transcripcional-del-gen-de-mitofusina-2-en-musculo-esqueletico\/","title":{"rendered":"Regulaci\u00f3n transcripcional del gen de mitofusina 2 en m\u00fasculo esquel\u00e9tico ."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francesc Xavier Soriano Zaragoza <\/strong><\/h2>\n<p>Resumen: mitofusina 2 (mfn2) es una prote\u00edna de fusi\u00f3n mitocondrial. Las evidencias experimentales demuestran una menor expresi\u00f3n g\u00e9nica de mfn2 en m\u00fasculo esquel\u00e9tico de sujetos obesos y pacientes diab\u00e9ticos de tipo 2. Al inhibir la expresi\u00f3n de mfn2 en c\u00e9lulas en cultivo se reduce el consumo de ox\u00edgeno, el potencial de membrana mitocondrial y la oxidaci\u00f3n de glucosa, indicando un papel relevante de mfn2 en la biolog\u00eda mitocondrial as\u00ed como en la fisiopatolog\u00eda de la obesidad y\/o la diabetes de tipo 2. Adem\u00e1s, se  han relacionado mutaciones en el gen de mfn2 con la neuropat\u00eda de charcot-marie-tooth de tipo 2 y se le ha descrito un papel antiproliferativo en desordenes vasculares. Consecuentemente, el estudio de la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica de mfn2 es de notable inter\u00e9s.  en esta tesis, se ha donado el promotor humano de mfn2 y se ha determinado que carece de caja tata y se localiza en una isla cpg, lo que lo hace susceptible de ser regulado por metilaci\u00f3n. En m\u00fasculo esquel\u00e9tico posee al menos 6 inicios de transcripci\u00f3n en una ventana de 171 pares de bases. Estudios con  genes reporteros han determinado que spl podr\u00eda tener un papel relevante dirigiendo a la maquinaria basal de transcripci\u00f3n para formar el complejo de preiniciaci\u00f3n. La expresi\u00f3n de mfn2 es mayor en tejidos con requerimientos energ\u00e9ticos elevados. Ensayos con genes reporteros han permitido identificar factores de transcripci\u00f3n que podr\u00edan ser responsables de la expresi\u00f3n dependiente de tejido.  se ha estudiado con detalle la inducci\u00f3n de mfn2 en m\u00fasculo esquel\u00e9tico y tejido adiposo marr\u00f3n con la exposici\u00f3n al fr\u00edo y tratamiento con agonistas de los receptores b3-adren\u00e9rgicos, condiciones ambas caracterizadaspor un elevado gasto energ\u00e9tico. El aumento de expresi\u00f3n de mfn2 en estas condiciones es  mediado por pgc-1a el cual coactiva a erra que se une al promotor de mfn2 en forma de mon\u00f3mero entre las bases -413 y -4<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n transcripcional del gen de mitofusina 2 en m\u00fasculo esquel\u00e9tico .<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n transcripcional del gen de mitofusina 2 en m\u00fasculo esquel\u00e9tico . <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francesc Xavier Soriano Zaragoza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zorzano Olarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: diego Haro bautista <\/li>\n<li>Antonio Serrano s\u00e1nchez (vocal)<\/li>\n<li>daniel Bach (vocal)<\/li>\n<li>pedro Marrero gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francesc Xavier Soriano Zaragoza Resumen: mitofusina 2 (mfn2) es una prote\u00edna de fusi\u00f3n mitocondrial. Las evidencias experimentales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,36483,160,940,17],"tags":[156988,20202,156989,34232,156987,19835],"class_list":["post-72156","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-molecular","category-bioquimica","category-genetica-bioquimica","category-quimica","tag-antonio-serrano-sanchez","tag-antonio-zorzano-olarte","tag-daniel-bach","tag-diego-haro-bautista","tag-francesc-xavier-soriano-zaragoza","tag-pedro-marrero-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72156"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72156\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72156"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}