{"id":72206,"date":"2018-03-09T23:16:58","date_gmt":"2018-03-09T23:16:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-los-inhibidores-endogenos-de-la-fibrinolisis-sobre-el-tratamiento-trombola%c2%adtico-del-ictus-cont-pa\/"},"modified":"2018-03-09T23:16:58","modified_gmt":"2018-03-09T23:16:58","slug":"influencia-de-los-inhibidores-endogenos-de-la-fibrinolisis-sobre-el-tratamiento-trombola%c2%adtico-del-ictus-cont-pa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-los-inhibidores-endogenos-de-la-fibrinolisis-sobre-el-tratamiento-trombola%c2%adtico-del-ictus-cont-pa\/","title":{"rendered":"Influencia de los inhibidores end\u00f3genos de la fibrin\u00f3lisis sobre el tratamiento trombol\u00edtico del ictus cont-pa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marc Ribo Jacobi <\/strong><\/h2>\n<p>Introducci\u00f3n  los inhibidores end\u00f3genos de la fibrinolisis juegan un papel esencial en el balance coagulaci\u00f3n\/fibrinolisis pudiendo estar involucrados en la respuesta al tratamiento trombol\u00edtico del ictus. Mientras que por una parte pueden inducir resistencia al t-pa limitado los beneficios de la tromb\u00f3lisis, por otra, pueden favorecer los procelosos de sangrado en las transformaciones hemorr\u00e1gicas.  objetivos  el objetivo de este estudio es determinar el impacto de los niveles pre-tratamiento de inhibidores de la fibrinolisis (inhibidor del activador del plasmin\u00f3geno (pai-1), lipoprote\u00edna(a), inhibidor de la fibrinolisis activado por trombina (tafi) y homociste\u00edna) sobre recanalizaci\u00f3n arterial, transformaci\u00f3n hemorr\u00e1gica sintom\u00e1tica (sich) y evoluci\u00f3n cl\u00ednica.  m\u00e9todos  estudiamos pacientes consecutivos en un ictus por oclusi\u00f3n de la arteria cerebral media tratados cont-pa. Se obtuvieron muestras de sangre justo antes de la administraci\u00f3n de t-pa para la determinaci\u00f3n de las mol\u00e9culas inhibidoras de la fibrinolisis. Se determin\u00f3 la recanalizaci\u00f3n arterial mediante monitorizaci\u00f3n contin\u00faa por doppler transcraneal. Una tomograf\u00eda computarizada craneal a las 24 horas o inmediatamente despu\u00e9s de observar un empeoramiento cl\u00ednico permiti\u00f3 descartar la presencia de una transformaci\u00f3n hemorr\u00e1gica sintom\u00e1tica. El estado neurol\u00f3gico se determin\u00f3 mediante la escala nihss y la discapacidad a largo plazo mediante la escala modificada de rankin (mrs) al tercer mes.  resultados  estudiamos 77 pacientes (40% mujeres, edad media 75 a\u00f1os). Al ingreso la mediana en la escala nihss fue de 17 (rango, 7a 22) y el tiempo medio de tratamiento desde el inicio de los s\u00edntomas fue de 160 minutos. En aquellos pacientes que presentaron una recanalizaci\u00f3n arterial despu\u00e9s de la infusi\u00f3n de t-pa se observaron niveles basales de pai-1 inferiores que en los que persisti\u00f3 la oclusi\u00f3n (27.8 ng\/ml vs 38.8 ng\/ml; p=0.047).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de los inhibidores end\u00f3genos de la fibrin\u00f3lisis sobre el tratamiento trombol\u00edtico del ictus cont-pa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de los inhibidores end\u00f3genos de la fibrin\u00f3lisis sobre el tratamiento trombol\u00edtico del ictus cont-pa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marc Ribo Jacobi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/12\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 \u00e1lvarez Sab\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>josep llu\u00eds Mart\u00ed vilalta (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Mercader sobrequ\u00e9s (vocal)<\/li>\n<li>Francisco Rubio borrego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marc Ribo Jacobi Introducci\u00f3n los inhibidores end\u00f3genos de la fibrinolisis juegan un papel esencial en el balance 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