{"id":72234,"date":"2005-10-01T00:00:00","date_gmt":"2005-10-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/envejecimiento-y-cronotoxilidao-neuroenoocrima-indulida-por-la-exposicion-al-cadmio\/"},"modified":"2005-10-01T00:00:00","modified_gmt":"2005-10-01T00:00:00","slug":"envejecimiento-y-cronotoxilidao-neuroenoocrima-indulida-por-la-exposicion-al-cadmio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/envejecimiento-y-cronotoxilidao-neuroenoocrima-indulida-por-la-exposicion-al-cadmio\/","title":{"rendered":"Envejecimiento y cronotoxilidao neuroenoocrima indulida por la exposici\u00f3n al cadmio."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anioal Gonz\u00e1lez Carracedo <\/strong><\/h2>\n<p>El cadmio es un perturbador neuroendocrino. Adem\u00e1s, al igual que otros muchos xenobi\u00f3ticos, presenta una cronotoxicidad importante. Por otro lado, las funciones fisiol\u00f3gicas se rigen seg\u00fan patrones cricadianos y circaestacionales, por lo que el cadmio podr\u00eda ejercer su toxicidad a trav\u00e9s de modificaciones en la actividad del reloj circadiano end\u00f3geno de los sistemas monoamin\u00e9rgicos cerebrales y del eje hipofisario-testicular. Asimismo, estos cambios ser\u00edan distintos seg\u00fan la \u00e9poca del a\u00f1o y la cepa o raza del animal de experimentaci\u00f3n, y su edad.  el objetivo de este trabajo es evaluar las alteraciones que induce el cadmio en el eje hipotal\u00e1mico-hipofisario-testicular y en estriado, en rata macho envejecida de la cepa wistar, desde el punto de vista cronobiol\u00f3gico. Para la consecuci\u00f3n de este objetivo se ha estudiado el ritmo circadiano de la concentraci\u00f3n de norepinefrina, dopamina y serotonina, y el metabolismo de estas dos \u00faltimas monoaminas en hipot\u00e1lamo, hip\u00f3fisis y test\u00edculo.  en este trabajo se han utilizado 288 ratas macho de la cepa wistar; 114 ratas adultas j\u00f3venes, de dos meses de vida,  y 144 ratas envejecida, de 18 meses. El cadmio se ha administrado a un grupo de 72 ratas adultas y 72 ratas envejecidas, en forma de cloruro  cadmio (cdcl2) disuelto en el agua de bebida, a una dosis de 25 ppm de cdcl2 durante 30 d\u00edas. A otras 144 ratas (72 adultas y 72 envejecidas) se ha administrado agua potable procedente del suministro de la facultad, y se utilizaci\u00f3n como controles del experimento. Los animales fueron sacrificados al final del tratamiento en subgrupos de doce ratas cada 4 horas a lo largo del d\u00eda. Se han determinado por hplc con detecci\u00f3n electroqu\u00edmica las monoaminas y sus metabolitos. los niveles plasm\u00e1ticos de lh y testorerona se han determinado por radioinmunoan\u00e1lisis, y la acumulaci\u00f3n del metal se ha determinado por espectrometr\u00eda de absorci\u00f3n at\u00f3mica.  a la vista de los resultados o<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Envejecimiento y cronotoxilidao neuroenoocrima indulida por la exposici\u00f3n al cadmio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Envejecimiento y cronotoxilidao neuroenoocrima indulida por la exposici\u00f3n al cadmio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anioal Gonz\u00e1lez Carracedo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Vigo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Anunciaci\u00f3n Lafuente Gim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: arturo ramon Anadon navarro <\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez v\u00e1zquez (vocal)<\/li>\n<li>nicolas Olea serrano (vocal)<\/li>\n<li>arturo Hardisson de la torre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anioal Gonz\u00e1lez Carracedo El cadmio es un perturbador neuroendocrino. Adem\u00e1s, al igual que otros muchos xenobi\u00f3ticos, presenta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,401,18657],"tags":[157121,10092,7412,18595,37292,3345],"class_list":["post-72234","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-toxicologia","category-vigo","tag-anioal-gonzalez-carracedo","tag-arturo-hardisson-de-la-torre","tag-arturo-ramon-anadon-navarro","tag-jose-antonio-rodriguez-vazquez","tag-maria-anunciacion-lafuente-gimenez","tag-nicolas-olea-serrano"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72234"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72234\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}