{"id":72235,"date":"2005-11-01T00:00:00","date_gmt":"2005-11-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/s-acilacion-de-protea%c2%adnas-y-translocacion-a-dominios-lipa%c2%addicos-de-baja-fluidez\/"},"modified":"2005-11-01T00:00:00","modified_gmt":"2005-11-01T00:00:00","slug":"s-acilacion-de-protea%c2%adnas-y-translocacion-a-dominios-lipa%c2%addicos-de-baja-fluidez","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/s-acilacion-de-protea%c2%adnas-y-translocacion-a-dominios-lipa%c2%addicos-de-baja-fluidez\/","title":{"rendered":"S-acilaci\u00f3n de prote\u00ednas y translocaci\u00f3n a dominios lip\u00eddicos de baja fluidez"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inmaculada Navarro L\u00e9rida <\/strong><\/h2>\n<p>El presente trabajo de investigaci\u00f3n est\u00e1 enfocado hacia el estudio de los mecanismos que subyacen al proceso de palmitoilaci\u00f3n de prote\u00ednas, centrando especial atenci\u00f3n a los mecanismos de regulaci\u00f3n de la isoforma inducible de la \u00f3xido n\u00edtrico sintasa.  dentro de nuestro af\u00e1n por seguir descubriendo nuevas prote\u00ednas modificadas por \u00e1cido palm\u00edticohemos descubierto que la inos se encuentra palmitoilada en su ciste\u00edna en posici\u00f3n 3, siendo esta modificaci\u00f3n necesaria para su regulaci\u00f3n tanto a nivel de la localizaci\u00f3n subcelular como de su actividad. sin embargo, y aunque la palmitolaci\u00f3n dela inos parece ser un punto clave de control de esta isoforma, su interacci\u00f3n con las caveolinas, especialmente con la caveolina-1 parece ser un nuevo mecanismo inhibitorio de regulaci\u00f3n espec\u00edfica de su actividad. En definitiva todos estos resultados apuntan a que la inos posee una funci\u00f3n dentro de la c\u00e9lula que va m\u00e1s all\u00e1 del mero papel de defensa celular que se le hab\u00eda atribuido hasta ahora y en el que es necesario seguir investigando.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S-acilaci\u00f3n de prote\u00ednas y translocaci\u00f3n a dominios lip\u00eddicos de baja fluidez<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S-acilaci\u00f3n de prote\u00ednas y translocaci\u00f3n a dominios lip\u00eddicos de baja fluidez <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inmaculada Navarro L\u00e9rida <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodr\u00edguez Crespo Jos\u00e9 Ignacio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alvaro Martinez  del pozo <\/li>\n<li> Alonso labrero Miguel angel (vocal)<\/li>\n<li>Santiago Lamas pel\u00e1ez (vocal)<\/li>\n<li>cristina Risco ortiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inmaculada Navarro L\u00e9rida El presente trabajo de investigaci\u00f3n est\u00e1 enfocado hacia el estudio de los mecanismos que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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