{"id":72291,"date":"2018-03-09T23:17:02","date_gmt":"2018-03-09T23:17:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizcion-del-factor-slug-como-represor-transcripcional-de-cadherina-e-en-la-progresion-tumoral-comparacion-con-snail\/"},"modified":"2018-03-09T23:17:02","modified_gmt":"2018-03-09T23:17:02","slug":"caracterizcion-del-factor-slug-como-represor-transcripcional-de-cadherina-e-en-la-progresion-tumoral-comparacion-con-snail","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizcion-del-factor-slug-como-represor-transcripcional-de-cadherina-e-en-la-progresion-tumoral-comparacion-con-snail\/","title":{"rendered":"Caracterizci\u00f3n del factor slug como represor transcripcional de cadherina-e en la progresion tumoral. comparaci\u00f3n con snail."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Bol\u00f3s Fern\u00e1ndez M. Victoria <\/strong><\/h2>\n<p>M\u00e1s del 90% eje los tumores humanos son carcinomas y la aparici\u00f3n de met\u00e1stasis es responsable de la muerte de la mayor parte de los pacientes con c\u00e1ncer. l\u00e1 cascada metast\u00e1sica de los carcinomas implica diferentes estadios: invasi\u00f3n local, intravasaci\u00f3n, extravasaci\u00f3n y finalmente, en un nuevo \u00f3rgano, la proliferaci\u00f3n de las c\u00e9lulas tumorales y aparici\u00f3n de tumores secundarios.  la invasi\u00f3n local de los carcinomas, requiere la p\u00e9rdida de la mol\u00e9cula de adhesi\u00f3n cadherina-e, esta observaci\u00f3n ha llevado a considerar cadherina-e como un gen supresor de invasi\u00f3n. Adicionalmente, el proceso de invasi\u00f3n suele ir acompa\u00f1ado de la p\u00e9rdida de otros marcadores epiteliales, la adquisici\u00f3n de marcadores mesenquim\u00e1ticos y el aumento de las propiedades migratorias, conocido conjuntamente como transici\u00f3n epitrelio-mes\u00e9nquima (tem), reminiscente a las tem del desarrollo embrionario. La represi\u00f3n  ranscripcional es uno de los principales mecanismos implicados en la regulaci\u00f3n del silenciamiento de la expresi\u00f3n de cadherina-e en el desarrollo y en la progresi\u00f3n de los carcinomas. Recientemente, se han identificado varios factores de transcripci\u00f3n que a trav\u00e9s de su interacci\u00f3n con las cajas-e del promotor de cadherina-e reprimen su expresi\u00f3n (snail, zeb-1, zeb-2, e47). En esta tesis se ha analizado la participaci\u00f3n de slug, otro miembro de la familia snail, y se ha caracterizado como represor de la expresi\u00f3n de cadherina-e. La expresi\u00f3n estable de slug en la l\u00ednea celular epitelial mdck reprime por completo la expresi\u00f3n de cadherina-e e induce una tem completa. El silenciamiento de la expresi\u00f3n de cadherina-e inducido por slug en mdck ocurre a nivel transcripcional.  sin embargo, el an\u00e1lisis de la afinidad de uni\u00f3n de diferentes represores por el elemento e-pal del promotor de cadherina-e de rat\u00f3n, indica que slug se une con menor afinidad que los represores snail y e47. Adicionalmente, nvestigamos los mecanismo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizci\u00f3n del factor slug como represor transcripcional de cadherina-e en la progresion tumoral. comparaci\u00f3n con snail.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizci\u00f3n del factor slug como represor transcripcional de cadherina-e en la progresion tumoral. comparaci\u00f3n con snail. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Bol\u00f3s Fern\u00e1ndez M. Victoria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amparo Cano Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Garesse alarc\u00f3n <\/li>\n<li>esteban Ballestar tarin (vocal)<\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bol\u00f3s Fern\u00e1ndez M. Victoria M\u00e1s del 90% eje los tumores humanos son carcinomas y la aparici\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9],"tags":[24375,157242,75741,40871,7832],"class_list":["post-72291","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","tag-amparo-cano-garcia","tag-bolos-fernandez-m-victoria","tag-esteban-ballestar-tarin","tag-isidro-javier-sanchez-garcia","tag-rafael-garesse-alarcon"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72291"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72291\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}