{"id":72329,"date":"2018-03-09T23:17:06","date_gmt":"2018-03-09T23:17:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-historia-natural-de-los-carcinomas-pulmonares-no-microciticos-con-diferenciacion-neuroendocrina-oculta\/"},"modified":"2018-03-09T23:17:06","modified_gmt":"2018-03-09T23:17:06","slug":"estudio-de-la-historia-natural-de-los-carcinomas-pulmonares-no-microciticos-con-diferenciacion-neuroendocrina-oculta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-historia-natural-de-los-carcinomas-pulmonares-no-microciticos-con-diferenciacion-neuroendocrina-oculta\/","title":{"rendered":"Estudio de la historia natural de los carcinomas pulmonares no microciticos con diferenciaci\u00f3n neuroendocrina oculta"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Cebollero Presmanes <\/strong><\/h2>\n<p>Introduci\u00f3n: existe controversia en la literatura sobre la relevancia cl\u00ednica de factores como la diferenciaci\u00f3n neuroendocrina oculta y la p\u00e9rdida de expresi\u00f3n de histoant\u00edgeno de grupo sangu\u00edneo a en los carcinomas pulmonares no microc\u00edticos.  material y m\u00e9todos: se han empleado en el estudio 154 casos de carcinomas epidermoides (76 casos)y adenocarcinomas (78 casos) resecados quir\u00fargicamente en estad\u00edos exclusivamente ia y ib . A todos ellos se les realiza estudio ultraestructural y una bater\u00eda inmunohistoqu\u00edmica que incluye tinciones para marcadores neuroendocrinos: sinaptofisina, leu-7 y cromogranima-a , as\u00ed como marcador de histoant\u00edgeno de grupo sangu\u00edneo a.  resultados: se demuestra expresi\u00f3n de al menos un marcador neuroendocrino en 56 casos (36,36%), independientemente del grado histol\u00f3gico de los mismos.Los adenocarcinomas demuestran mayor porcentaje de positividad para cualquier de los tres marcadores (34,6% para sinaptofisina , 12,8% para cromogranina y 12,8% para leu 7).Los carcinomas epidermoides expresan en porcentajes m\u00e1s bajos: 26,3%j para sinaptofisina , 9,2% para cromogranina y 1,3% para leu-7.Los pacientes con tumores que expresan al menos un 10% de c\u00e9lulas positivas para sinaptofisina muestran reducci\u00f3n de la supervivencia estad\u00edsticamente significativa: 68 meses frente a 103 meses en los pacientes con tumores negativos ( p 0,0104).Muestran adem\u00e1s mayores tasas de recurrencia de la enfermedad: 36,17% frente a 20,5%en los casos negativos (p 0,03).Dentro del grupo depacientes estudiado, se encuentra un subgrupo de 78 pacientes que pertenecen al grupo sangu\u00edneo a.De ellos , 41,03% no expresan ant\u00edgeno de grupo a en el tejido tumoral.Este grupo tambi\u00e9n demuestra un curso cl\u00ednico m\u00e1s agresivo de forma estad\u00edsticamente significativa, con reducci\u00f3n dela supervivencia (p 0,0148)  y mayor tasas de recurrencia (p 0,042).  conclusiones: los adenocarcinomas y carcinomas epidermoides pulmonares en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la historia natural de los carcinomas pulmonares no microciticos con diferenciaci\u00f3n neuroendocrina oculta<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la historia natural de los carcinomas pulmonares no microciticos con diferenciaci\u00f3n neuroendocrina oculta <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Cebollero Presmanes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Fernandez Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: juli\u00e1n Sanz esponera <\/li>\n<li>Antonio Llombart bosch (vocal)<\/li>\n<li>felix Contreras rubio (vocal)<\/li>\n<li>eduardo Garcia poblete (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Cebollero Presmanes Introduci\u00f3n: existe controversia en la literatura sobre la relevancia cl\u00ednica de factores como la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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