{"id":72348,"date":"2018-03-09T23:17:06","date_gmt":"2018-03-09T23:17:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hiperglucemia-y-su-correccion-en-el-trasplante-alogenico-de-islotes-de-pancreas\/"},"modified":"2018-03-09T23:17:06","modified_gmt":"2018-03-09T23:17:06","slug":"hiperglucemia-y-su-correccion-en-el-trasplante-alogenico-de-islotes-de-pancreas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hiperglucemia-y-su-correccion-en-el-trasplante-alogenico-de-islotes-de-pancreas\/","title":{"rendered":"Hiperglucemia y su correcci\u00f3n en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Carlos Ferrer Garc\u00eda <\/strong><\/h2>\n<p>El protocolo de edmonton ha establecido que la independencia de la insulina puede conseguirse con el trasplante  de un adecuado n\u00famero de islotes. sin embargo, para lograr este resultado son necesarios de dos a cuatro p\u00e1ncreas donantes.  objetivos: el objetivo de esta tesis fue determinar si la normoglucemia, obtenida con tratamiento insul\u00ednico los d\u00edas que preceden y siguen al trasplante, reduce el n\u00famero de islotes necesario para obtener la normoglucemia en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas.  material y m\u00e9todos: los trasplantes se realizaron sobre un modelo experimental alog\u00e9nico, utilizando ratones swiss como donantes y receptores. Para inducir la diabetes se utiliz\u00f3 estreptozotocina intraperitoneal a una dosis de 180 mg\/kg. Los ratones diab\u00e9ticos fueron trasplantados con 300 (n=16), 400 (n=16) y 500 (n=16) islotes bajo la c\u00e1psula renal izquierda. En cada grupo, la mitad de los animales se mantuvieron normogluc\u00e9micos mediante tratamiento con insulina desde el d\u00eda 6 antes del trasplante hasta el d\u00eda 10 post-trasplante. Como terapia inmunosupresora se utiliz\u00f3 ciclosporina en soluci\u00f3n oleosa, administrada v\u00eda subcut\u00e1nea el d\u00eda del trasplante y los d\u00edas 1 y 2 post-trasplante, a una dosis de 30 mg\/kg\/d\u00eda. Los animales que se mantuvieron normogluc\u00e9micos al final del estudio fueron sometidos a un test de tolerancia intraperitoneal a la glucosa (ttipg). Todos los resultados se compararon con un grupo control de animales sanos, no diab\u00e9ticos, no trasplantados y no tratados con insulina. Para el an\u00e1lisis estad\u00edstico se utiliz\u00f3 el software spss versi\u00f3n 10.0, empleando el test t de student para comparar dos grupos y el an\u00e1lisis de la varianza para comparar varios grupos, con pruebas param\u00e9tricas o no, seg\u00fan procediera.  resultados: en el grupo de animales trasplantados y no tratados  con insulina, s\u00f3lo uno trasplantado con 500 islotes (13%) mantuvo la normoglucemia al final del estudio. Por el contra<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hiperglucemia y su correcci\u00f3n en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hiperglucemia y su correcci\u00f3n en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Carlos Ferrer Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Merino Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antonino Jara albarr\u00e1n <\/li>\n<li>eduard Montanya fr\u00edas (vocal)<\/li>\n<li>pedro Costa talens (vocal)<\/li>\n<li> Ponce marco Jos\u00e9 lu\u00eds (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Carlos Ferrer Garc\u00eda El protocolo de edmonton ha establecido que la independencia de la insulina puede [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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