{"id":72351,"date":"2018-03-09T23:17:06","date_gmt":"2018-03-09T23:17:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-cd5-en-la-leucemia-linfoide-cronica-de-celula-b-llcb\/"},"modified":"2018-03-09T23:17:06","modified_gmt":"2018-03-09T23:17:06","slug":"implicacion-del-cd5-en-la-leucemia-linfoide-cronica-de-celula-b-llcb","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-del-cd5-en-la-leucemia-linfoide-cronica-de-celula-b-llcb\/","title":{"rendered":"Implicacion del cd5 en la leucemia linfoide cronica de celula b (llcb)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gema Perez Chacon <\/strong><\/h2>\n<p>La leucemia linfoide cr\u00f3nica de c\u00e9lulas b (llc-b) es la leucemia m\u00e1s frecuente en el mundo occidental. Est\u00e1 caracterizada por una expansi\u00f3n clonal de linfocitos b cd5+ que se van acumulando lenta y progresivamente en sangre, pudiendo infiltrar m\u00e9dula \u00f3sea, ganglios linf\u00e1ticos y bazo. Cl\u00ednicamente los pacientes presentan un desarrollo muy heterog\u00e9neo, ya que se distinguen pacientes con una prolongada supervivencia y que no requieren tratamiento frente a otros con un r\u00e1pido desarrollo de la enfermedad y resistentes a la terapia. Actualmente se piensa que esta heterogeneidad se debe a la diferente capacidad de respuesta frente a ant\u00edgeno de las c\u00e9lula tumorales. se sabe que la respuesta frente a ant\u00edgeno depende de la funcionalidad del receptor espec\u00edfico de ant\u00edgeno (bcr), as\u00ed como de se\u00f1ales adicionales de glicoprote\u00ednas moduladolas asociadas a \u00e9ste. Entre \u00e9stas se encuentra el cd5, que funciona como un regulador negativo de la se\u00f1alizaci\u00f3n v\u00eda bcr.  en este trabajo se estudi\u00f3 la posible relaci\u00f3n enrte la mol\u00e9cula cd5 y la expansi\u00f3n clonal que caracteriza a esta patolog\u00eda. Se observ\u00f3 que, a diferencia que en c\u00e9lulas b sanas, las se\u00f1ales de viabilidad, apoptosis o proliferaci\u00f3n en respuesta a est\u00edmulos anti-bcr no resultaban afectadas por la ausencia de cd5 en las c\u00e9lulas tumorales. Esto parec\u00eda indicar que cd5 no ejerc\u00eda un efecto inhibidor sobre la se\u00f1alizaci\u00f3n iniciada a trav\u00e9s del bcr en estas c\u00e9lulas, hecho que puede estar relacionado con la expansi\u00f3n tumoral.  sin embargo, esta falta de modulaci\u00f3n no parec\u00eda debida a defectos en la v\u00eda de se\u00f1alizaci\u00f3n de cd5, puesto que anticuerpos anti-cd5 induc\u00edan apoptosis o viabilidad seg\u00fan       la dosis de anticuerpo empleada. Cd5 era capaz de disparar eventos inmediatos de activaci\u00f3n como la fosforilaci\u00f3n de prote\u00ednas tirosinas quinasa y la posterior inducci\u00f3n de la prote\u00edna antiapopt\u00f3tica mcl-1, por una v\u00eda dependiente de la activaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion del cd5 en la leucemia linfoide cronica de celula b (llcb)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion del cd5 en la leucemia linfoide cronica de celula b (llcb) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gema Perez Chacon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Perez Aciego De Mendoza Paloma<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mart\u00ednez l\u00f3pez de letona Juan <\/li>\n<li>julia Jorda tormo (vocal)<\/li>\n<li>josef\u00edna Men\u00e9ndez s\u00e1nchez (vocal)<\/li>\n<li>joan Gil santano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gema Perez Chacon La leucemia linfoide cr\u00f3nica de c\u00e9lulas b (llc-b) es la leucemia m\u00e1s frecuente en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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