{"id":72403,"date":"2018-03-09T23:17:10","date_gmt":"2018-03-09T23:17:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-multiparametrico-del-clon-tumoral-en-la-macroglobulinemia-de-waldenstra%c2%b6m\/"},"modified":"2018-03-09T23:17:10","modified_gmt":"2018-03-09T23:17:10","slug":"estudio-multiparametrico-del-clon-tumoral-en-la-macroglobulinemia-de-waldenstra%c2%b6m","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-multiparametrico-del-clon-tumoral-en-la-macroglobulinemia-de-waldenstra%c2%b6m\/","title":{"rendered":"Estudio multiparametrico del clon tumoral en la macroglobulinemia de waldenstr\u00c1\u00b6m"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique M\u00aa Ocio San Miguel <\/strong><\/h2>\n<p>El concepto de la macroglobulinemia de waldenstr\u00ed\u00b6m (mw) es a\u00fan controvertido y persisten numerosas lagunas sobre las caracter\u00edsticas del clon tumoral. en el presente trabajo se ha realizado un estudio multiparam\u00e9trico (inmunofenot\u00edpico, citogen\u00e9tico\/hisf y de contenido de adn) destinado a caracterizar mejor el clon tumoral y sus diferentes componentes.  se describe el patr\u00f3n inmunofenot\u00edpico caracter\u00edstico de las diferentes subpoblaciones del clon tumoral. La positividad para cd25 junto con la positividad d\u00e9bil de cd22 es caracter\u00edstico de los lb de la mw. Tanto los linfocitos b como los linfoplasmocitos y las c\u00e9lulas plasm\u00e1ticas forman parte del mismo clon tumoral, teniendo caracter\u00edsticas antig\u00e9nicas singulares.  el an\u00e1lisis del contenido de adn y del ciclo celular indica que las gammapat\u00edas monoclonales igm, a diferencia del mieloma m\u00faltiple y de las gmsi no igm, son diploides y adem\u00e1s son poco proliferativas, sin observarse diferencias entre la mw y las gmsi igm. El estudio de los linfocitos b y de las c\u00e9lulas plasm\u00e1ticas por separado, sugiere que ambas subpoblaciones contribuyen de forma similar a proliferaci\u00f3n tumoral.  con respecto a las caracter\u00edsticas citogen\u00e9ticas y de hisf (hibridaci\u00f3n in situ fluorescente), la mw tiene una incidencia baja de anomal\u00edas cariot\u00edpicas. la deleci\u00f3n del brazo largo del cromosoma 6 es la alteraci\u00f3n m\u00e1s frecuentemente encontrada (30%) tanto por citogen\u00e9tica convencional como por hisf y se asocia con peor pron\u00f3stico. Otras alteraciones menos frecuentes son la traslocaci\u00f3n de 14q32 (15%) y la deleci\u00f3n de rb y tp53 (&lt;5%). El an\u00e1lisis de hisf en c\u00e9lulas separadas mediante \u00abfacs-sorting\u00bb indica que tanto los linfocitos b como las c\u00e9lulas plasm\u00e1ticas muestran las mismas alteraciones citogen\u00e9ticas, aludiendo a su pertenencia al mismo clon tumoral.  el inmunofenotipo y la citogen\u00e9tica pueden contribuir a diferenciar la mw de otros s\u00edndromes linfoproliferativos com<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio multiparametrico del clon tumoral en la macroglobulinemia de waldenstr\u00c1\u00b6m<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio multiparametrico del clon tumoral en la macroglobulinemia de waldenstr\u00c1\u00b6m <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique M\u00aa Ocio San Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Fernando San Miguel Izquierdo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Rios gonzalez <\/li>\n<li>joan Blade creixenti (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Moraleda jim\u00e9nez (vocal)<\/li>\n<li>Juan  Jos\u00e9 Lahuerta palacios (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique M\u00aa Ocio San Miguel El concepto de la macroglobulinemia de waldenstr\u00ed\u00b6m (mw) es a\u00fan controvertido y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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