{"id":72440,"date":"2018-03-09T23:17:14","date_gmt":"2018-03-09T23:17:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-proteinas-asociadas-a-apoptosis-y-resistencia-a-multiples-farmacos-en-leucemia-mieloblastica-aguda-y-sindrome-mielodisplasicos\/"},"modified":"2018-03-09T23:17:14","modified_gmt":"2018-03-09T23:17:14","slug":"expresion-de-proteinas-asociadas-a-apoptosis-y-resistencia-a-multiples-farmacos-en-leucemia-mieloblastica-aguda-y-sindrome-mielodisplasicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hematologia\/expresion-de-proteinas-asociadas-a-apoptosis-y-resistencia-a-multiples-farmacos-en-leucemia-mieloblastica-aguda-y-sindrome-mielodisplasicos\/","title":{"rendered":"Expresion de proteinas asociadas a apoptosis y resistencia a multiples farmacos en leucemia mieloblastica aguda y sindrome mielodisplasicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Suarez Batista Lilia Esther <\/strong><\/h2>\n<p>Se han comunicado resultados contradictorios sobre apoptosis y resistencia a m\u00faltiples f\u00e1rmacos (rmf) en leucemias mielobl\u00e1sticas agudas (lma) y s\u00edndromes mielodispl\u00e1sicos (smd). Se evalu\u00f3 la expresi\u00f3n cuantitativa de prote\u00ednas asociadas a apoptosis (apo2.7, bcl-2, bax) y\/o rmf (gp-p, mrp, lrp) en blastos con diferente grado de maduraci\u00f3n en pacientes con lma de edad avanzada ( 65 a\u00f1os) y en un grupo control de menos edad ( 65 a\u00f1os), en c\u00e9lulas cd34+ de pacientes con lma, smd-alto (smd-ar) y bajo riesgo (smd-br) y en diferentes compartimientos celulares cd34- en smd. Se estudiaron muestras de m\u00e9dula \u00f3sea (mo) al diagn\u00f3stico de pacientes: con lma de novo (150 de edad avanzada y 30 m\u00e1s j\u00f3venes), 21 con smd-br y 9 con smd-ar y 12 mo normales (mon). Se utilizaron t\u00e9cnicas de inmunofluorescencia de 4-colores y una estrategia de an\u00e1lisis multiparam\u00e9trico mediante citometr\u00eda de flujo. la expresi\u00f3n de dichas prote\u00ednas var\u00eda con la maduraci\u00f3n de los blastos en las lma. Los blastos cd34+ mostraron un fenotipo anti-apopt\u00f3tico m\u00e1s acentuado que los blastos cd34-. La expresi\u00f3n de gp-p y mrp1 disminuye y lrp aumenta paralelamente a la maduraci\u00f3n de los blastos mieloides. Sin embargo, en los pacientes de edad avanzada es m\u00e1s frecuente que los blastos leuc\u00e9micos muestren un fenotipo inmaduro y homog\u00e9neo cd34+, lo que podr\u00eda condicionar un comportamiento biol\u00f3gico diferente con una mayor resistencia a la quimioterapia en ese grupo de pacientes. Los precursores neopl\u00e1sicos cd34+ de lma y smd-ar presentaron un fenotipo apopt\u00f3tico y rmf muy similar, mientras que el de las c\u00e9lulas cd34+ de smd-br es similar a la mon y diferente del observado en lma y smd-ar. En los smd-br, las c\u00e9lulas eritroides y granulomonoc\u00edticas cd34- de mo mostraron un patr\u00f3n fenot\u00edpico pro-apopt\u00f3tico anormalmente acentuado, mientras que en los smd-ar, las diferencias respecto a la mon son menores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de proteinas asociadas a apoptosis y resistencia a multiples farmacos en leucemia mieloblastica aguda y sindrome mielodisplasicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de proteinas asociadas a apoptosis y resistencia a multiples farmacos en leucemia mieloblastica aguda y sindrome mielodisplasicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Suarez Batista Lilia Esther <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Rios gonzalez <\/li>\n<li>guillermo Sanz santillana (vocal)<\/li>\n<li>joaqu\u00edn D\u00edaz mediavilla (vocal)<\/li>\n<li>Fernando Ramos ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Suarez Batista Lilia Esther Se han comunicado resultados contradictorios sobre apoptosis y resistencia a m\u00faltiples f\u00e1rmacos (rmf) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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