{"id":72444,"date":"2018-03-09T23:17:14","date_gmt":"2018-03-09T23:17:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-repertorio-de-autoanticuerpos-en-la-esclerosis-sistemica\/"},"modified":"2018-03-09T23:17:14","modified_gmt":"2018-03-09T23:17:14","slug":"analisis-del-repertorio-de-autoanticuerpos-en-la-esclerosis-sistemica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/reumatologia\/analisis-del-repertorio-de-autoanticuerpos-en-la-esclerosis-sistemica\/","title":{"rendered":"Analisis del repertorio de autoanticuerpos en la esclerosis sistemica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Garcia De La Pe\u00f1a Lefebvre <\/strong><\/h2>\n<p>1.\tEl repertorio de reactividades de la igg s\u00e9ricas de los tres grupos de pacientes es diferente cuando se compara entre ellos y con el sujeto sano, particularmente frete a extractos proteicos de c\u00e9lula endotelial y hep2 2.\tLas igg s\u00e9ricas de los pacients con aat1 se unen fuertemente a un ag de 100 kd frente a extractos proteicos de huvec, hmvec-i y hmvec-d y en un menor grado frente a extractos de pulm\u00f3n, ri\u00f1\u00f3n y es\u00f3fago. El 50% de los pacients sin aat1 ni aac reaccionaban con la misma banda frente a extractos de huvec. 3.\tPor primera vez se ha identificado como fuente de aace de tipo igg a la adn topoisomerasa 1 en pacientes con escd con actividad aat1 conocida por otras t\u00e9cnicas pero tambi\u00e9n por el 50% de los pacientes sin aat1.  4.\tLas igg s\u00e9ricas de los pacientes con aac reaccionan espec\u00edficamente frente a una banda de 80 kd frente a extractos de hmvec-1 y hmvec-d pero no frente a huvec. 5.\tDe estos resultados se podr\u00edan concluir que los ag de c\u00e9lula endotelial reconocidos por las igg de los pacientes con escd son comunes al endotelio de la microcirculaci\u00f3n y de la macrocirculaci\u00f3n, mientras que los reconocidos por las igg de los pacientes con escl serian espec\u00edficos de la microcirculaci\u00f3n, aunque son necesarios mas estudios para confirmarlo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis del repertorio de autoanticuerpos en la esclerosis sistemica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis del repertorio de autoanticuerpos en la esclerosis sistemica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Garcia De La Pe\u00f1a Lefebvre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luc Mouthon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>Jes\u00fas m. Corres gonzalez (vocal)<\/li>\n<li>garbi\u00f1e Roy ari\u00f1e (vocal)<\/li>\n<li>Jos\u00e9 Luis Pablos alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Garcia De La Pe\u00f1a Lefebvre 1. El repertorio de reactividades de la igg s\u00e9ricas de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,877],"tags":[157548,106283,62668,157547,14431,157546],"class_list":["post-72444","post","type-post","status-publish","format-standard","hentry","category-alcala","category-reumatologia","tag-garbine-roy-arine","tag-jesus-m-corres-gonzalez","tag-jose-luis-pablos-alvarez","tag-luc-mouthon","tag-melchor-alvarez-de-mon-soto","tag-paloma-garcia-de-la-pena-lefebvre"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72444"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72444\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}