{"id":72455,"date":"2018-03-09T23:17:14","date_gmt":"2018-03-09T23:17:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-interstitial-cells-of-cajal-in-the-pacemaker-activity-and-neurotransmission-in-the-rat-colon\/"},"modified":"2018-03-09T23:17:14","modified_gmt":"2018-03-09T23:17:14","slug":"role-of-interstitial-cells-of-cajal-in-the-pacemaker-activity-and-neurotransmission-in-the-rat-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/role-of-interstitial-cells-of-cajal-in-the-pacemaker-activity-and-neurotransmission-in-the-rat-colon\/","title":{"rendered":"Role of interstitial cells of cajal in the pacemaker activity and neurotransmission in the rat colon"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Albert\u00ed Mart\u00ednez De Velasco Elena <\/strong><\/h2>\n<p>Los objetivos de esta tesis han sido investigar el papel de las c\u00e9lulas intersticiales de cajal (iccs) en la actividad marcapasos y la transmisi\u00f3n neuromuscular en el tracto gastrointestinal. El estudio se ha realizado en el colon porque en esta parte del tracto gastrointestinal los mecanismos marcapasos y de neurotransmisi\u00f3n son poco conocidos. El modelo de rata se ha utilizado porque estudios previos, realizados en nuestro laboratorio, mostraron un marcapasos de origen miog\u00e9nico, tambi\u00e9n descrito en el colon humano. Adem\u00e1s, las ratas ws\/ws presentan una mutaci\u00f3n en el gen c-kit que afecta el normal desarrollo de determinadas l\u00edneas celulares, inlcuidas las iccs. Por lo tanto, hemos utilizado tres grupos de animales: ratas sprague-dawley, mutantes ws\/ws y sus hermanas controles +\/+. Para investigar la actividad marcapasos y la neurotransmisi\u00f3n realizamos:  1,- tinciones immunohistoqu\u00edmicas con anticuerpos c-kit y nos para marcar iccs y neuronas nitr\u00e9rgicas, respectivamente.  2,- estudios de la actividad mec\u00e1nica mediante el uso de un ba\u00f1o de \u00f3rganos.  3,- registros el\u00e9ctricos mediante la t\u00e9cnica de microelectrodos intracelulares.  nuestros estudios muestran dos redes de iccs en el colon de la rata, a nivel de los plexos de auerbach (icc-ap, 100 c\u00e9lulas\/mm2) y submuscular (icc-smp, 50-60 c\u00e9lulas\/mm2).  las iccs intramurales (icc-im) se encontraron distribuidas de forma paralela entre las c\u00e9lulas musculares lisas.  obtuvimos resutlados similares en las ratas sprague-dawley y +\/+. En cambio, las ratas mutantes ws\/ws presentaron una marcada disminuci\u00f3n de inmunoreactividad al c-kit. Las ratas sprague-dawley presentaron una actividad el\u00e9ctrica espont\u00e1nea formada por ondas lentas y despolarizaciones c\u00edclicas, siguiendo un patr\u00f3n regular. Esta actividad el\u00e9ctrica da lugar a contracciones de alta y baja frecuencia, respectivamente. Las contracciones de alta y baja frecuencia var\u00edan en relaci\u00f3n a la orientaci\u00f3n de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Role of interstitial cells of cajal in the pacemaker activity and neurotransmission in the rat colon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Role of interstitial cells of cajal in the pacemaker activity and neurotransmission in the rat colon <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Albert\u00ed Mart\u00ednez De Velasco Elena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marcel Jim\u00e9nez Farrerons<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Go\u00f1alons sintes <\/li>\n<li>Javier Santos (vocal)<\/li>\n<li>de Giorgio fernando (vocal)<\/li>\n<li>pere Clav\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Albert\u00ed Mart\u00ednez De Velasco Elena Los objetivos de esta tesis han sido investigar el papel de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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