{"id":72496,"date":"2018-03-09T23:17:18","date_gmt":"2018-03-09T23:17:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/transportadores-heteromericos-de-aminoacidos-analisis-mutacional-de-rbat-en-cistinuria-y-estudios-de-relacion-estructura-funcion\/"},"modified":"2018-03-09T23:17:18","modified_gmt":"2018-03-09T23:17:18","slug":"transportadores-heteromericos-de-aminoacidos-analisis-mutacional-de-rbat-en-cistinuria-y-estudios-de-relacion-estructura-funcion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/transportadores-heteromericos-de-aminoacidos-analisis-mutacional-de-rbat-en-cistinuria-y-estudios-de-relacion-estructura-funcion\/","title":{"rendered":"Transportadores heterom\u00e9ricos de amino\u00e1cidos: an\u00e1lisis mutacional de rbat en cistinuria y estudios de relaci\u00f3n estructura-funci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Maite Jim\u00e9nez Vidal <\/strong><\/h2>\n<p>Los transportadores heterom\u00e9ricos de amino\u00e1cidos (hat) est\u00e1n formados por una subunidad ligera (lshat) y una subunidad pesada (hshat) unidas entre ellas mediante un puente disulfuro.  se han descrito dos hshat; rbat y 4f2hc. Son glicoprote\u00ednas de membrana de tipo ii, con un extremo n-terminal intracelular, un \u00fanico dominio trans-membrana y un extremo c-terminal extracelular hom\u00f3logo a las alfa-amilasas.  hasta el momento se han identificado 9 lshats: 6 se unen a 4f2hc para dar lugar al transportador funcional (lat-1, lat-2, y+lat-1 y y+lat-2, asc-1, xct) una se une a rbat (bo+ at) y existen dos miembros \u00abhu\u00e9rfanos\u00bb (asc-2, agt-1), que no interaccionan con las hshats descritas y que quiz\u00e1s se unen a hshats todav\u00eda por identificar. Las diferentes lshat presentan las siguientes caracter\u00edsticas estructurales y funcionales comunes:  1,- son prote\u00ednas altamente hidrof\u00f3bicas no glicosiladas.  2,- presentan una predicci\u00f3n de estructura de 12 segmentos trans-membrana, con extremos n y c-terminal intracelulares. Esta topolog\u00eda se ha demostrado para la subunidad ligera xct, que presenta adem\u00e1s un reentrant-loop, entre los segmentos trans-membrana 2 y 3, con evidencias funcionales de su proximidad a la v\u00eda de translocaci\u00f3n de sustrato.  3,- el residuo de cisteina conservado que interviene en la formaci\u00f3n del puente disulfuro se encuentra localizado en el dominio extracelular putativo ii.  4,- necesitan la coexpresi\u00f3n de la hshat para alcanzar la membrana plasm\u00e1tica en un sistema de expresi\u00f3n heter\u00f3logo.  5,- confieren la especificidad de transporte al complejo heterom\u00e9rico, representando una gran diversidad de sustratos y acoplamiento a iones: amino\u00e1cidos neutros de tama\u00f1o grande (lat-1, lat-2), peque\u00f1o (asc-1, lat-2), cargados negativamente (xct) y amino\u00e1cidos b\u00e1sicos y neutros (y+lat-1, y+lat-2 y bo,+at).  6,- se comportan como intercambiadores obligatorios con una estequiometr\u00eda 1:1 y con una afinidad intracel<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Transportadores heterom\u00e9ricos de amino\u00e1cidos: an\u00e1lisis mutacional de rbat en cistinuria y estudios de relaci\u00f3n estructura-funci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Transportadores heterom\u00e9ricos de amino\u00e1cidos: an\u00e1lisis mutacional de rbat en cistinuria y estudios de relaci\u00f3n estructura-funci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Maite Jim\u00e9nez Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/01\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Palac\u00edn Prieto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Rodriguez de cordoba <\/li>\n<li>ignacio Fita (vocal)<\/li>\n<li>beatriz L\u00f3pez corcuera (vocal)<\/li>\n<li>n\u00faria Sala (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Maite Jim\u00e9nez Vidal Los transportadores heterom\u00e9ricos de amino\u00e1cidos (hat) est\u00e1n formados por una subunidad ligera (lshat) y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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