{"id":72589,"date":"2005-04-02T00:00:00","date_gmt":"2005-04-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-la-dopamina-en-los-procesos-degenerativos-del-sistema-nigroestriado\/"},"modified":"2005-04-02T00:00:00","modified_gmt":"2005-04-02T00:00:00","slug":"implicacion-de-la-dopamina-en-los-procesos-degenerativos-del-sistema-nigroestriado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/implicacion-de-la-dopamina-en-los-procesos-degenerativos-del-sistema-nigroestriado\/","title":{"rendered":"Implicaci\u00f3n de la dopamina en los procesos degenerativos del sistema nigroestriado"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roc\u00edo Mart\u00ednez De Pablos <\/strong><\/h2>\n<p>La enfermedad de parkinson afecta al 1% de las personas mayores de 50 a\u00f1os. Causada por la p\u00e9rdida del neurotransmisor dopamina su patog\u00e9nesis no se conoce bien, aunque se piensa que la inflamaci\u00f3n podr\u00eda estar implicada en el desarrollo de esta neurodegeneraci\u00f3n. Con el fin de estudiar esta posibilidad nuestro grupo desarroll\u00f3 un modelo animal de parkinson por inflamaci\u00f3n mediante la inyecci\u00f3n del proinflamatorio lipopolisac\u00e1rido. La estructura cerebral m\u00e1s sensible a este compuesto result\u00f3 ser la sustancia negra, estructura especialmente implicada en el parkinson. En este estudio nos propusimos buscar las causas de esta especial sensibilidad, estudiando la posible influencia de la propia dopamina en el proceso degenerativo inducido por la inyecci\u00f3n de lipopolisac\u00e1rido: nuestros resalados muestran que la acci\u00f3n degenerativa del lipopolisac\u00e1rido parece mediada por la dopamina end\u00f3gena a trav\u00e9s de un mecanismo de acci\u00f3n espec\u00edfico. El descubrimiento de este mecanismo es de gran importancia para el desarrollo de nuevos f\u00e1rmacos que nos permitan luchar contra este proceso degenerativo y por tanto contra la aparici\u00f3n de la enfermedad. Asimismo nuestro estudio proporciona una explicaci\u00f3n al hecho de que uno de los tratamientos m\u00e1s utilizados en la actualidad, la levodopa, pueda acelerar la progresi\u00f3n de la degeneraci\u00f3n neuronal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n de la dopamina en los procesos degenerativos del sistema nigroestriado<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n de la dopamina en los procesos degenerativos del sistema nigroestriado <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roc\u00edo Mart\u00ednez De Pablos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/02\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josefina Cano Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Machado de la quintana <\/li>\n<li>Jos\u00e9 Antonio Pintor toro (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Delgado Garc\u00eda (vocal)<\/li>\n<li> Venero recio Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roc\u00edo Mart\u00ednez De Pablos La enfermedad de parkinson afecta al 1% de las personas mayores de 50 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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