{"id":7266,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/desarrollo-y-aplicacion-de-nuevos-metodos-para-la-identificacion-de-genes-expresados-diferencialmente-en-el-tumor-de-ewing\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"desarrollo-y-aplicacion-de-nuevos-metodos-para-la-identificacion-de-genes-expresados-diferencialmente-en-el-tumor-de-ewing","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/desarrollo-y-aplicacion-de-nuevos-metodos-para-la-identificacion-de-genes-expresados-diferencialmente-en-el-tumor-de-ewing\/","title":{"rendered":"Desarrollo y aplicacion de nuevos metodos para la identificacion de genes expresados diferencialmente en el tumor de ewing."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonzalez Lamu\u00f1o Leguina Domingo <\/strong><\/h2>\n<p>Se han desarrollado diferentes estrategias basadas en tecnicas moleculares para identificar genes con expresion restringida al tumor de ewing en una primera estrategia, se han amplificado adnc de dominios cataliticos de genes para serina-treonina quinasas, seguido de una hibridacion diferencial respecto a otra linea celular de linaje diferente con este metodo hemos aislado un adnc que en northern blots reconoce un transcrito con expresion restringida al tumor de ewing y melanoma y que tiene similitudes con una quinasa de m.Xantus. Este resultado apoya el posible origen comun de ambos tumores en la cresta neural tambien desarrollamos un nuevo metodo basado en la pcr, para la generacion y posterior comparacion de improntados a partir de arn hemos identificado la expresion del gen znf43, que codifica para una proteina reguladora negativa de la transcripcion, expresada en lineas celulares de diversos tumores de celulas peque\u00f1as (t. De ewing), y cuya expresion disminuye drasticamente en las lineas celulares diferenciadas la alta expresion de este gen en el t. De ewing se relaciona con su fenotipo indiferenciado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y aplicacion de nuevos metodos para la identificacion de genes expresados diferencialmente en el tumor de ewing.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y aplicacion de nuevos metodos para la identificacion de genes expresados diferencialmente en el tumor de ewing. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonzalez Lamu\u00f1o Leguina Domingo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Garcia Fuentes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Teresa Delgado Macias <\/li>\n<li>Javier Le\u00f3n Serrano (vocal)<\/li>\n<li>Manuel Bueno Sanchez (vocal)<\/li>\n<li>Juan Rodriguez Soriano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalez Lamu\u00f1o Leguina Domingo Se han desarrollado diferentes estrategias basadas en tecnicas moleculares para identificar genes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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