{"id":72744,"date":"2018-03-09T23:17:33","date_gmt":"2018-03-09T23:17:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-de-la-melatonina-en-las-enfermedades-autoinmunes-artritis-reumatoide-y-lupus-eritemaposo-sitemico\/"},"modified":"2018-03-09T23:17:33","modified_gmt":"2018-03-09T23:17:33","slug":"accion-de-la-melatonina-en-las-enfermedades-autoinmunes-artritis-reumatoide-y-lupus-eritemaposo-sitemico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/accion-de-la-melatonina-en-las-enfermedades-autoinmunes-artritis-reumatoide-y-lupus-eritemaposo-sitemico\/","title":{"rendered":"Acci\u00f3n de la melatonina en las enfermedades autoinmunes: artritis reumatoide y lupus eritemaposo sit\u00e9mico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Jim\u00e9nez Caliani Antonio  Javier <\/strong><\/h2>\n<p>Recientemente se ha abierto y descubierto un nuevo campo de estudio de la metatonina y su acci\u00f3n sobre el sistema inmune.Ampliando este estudio, decidimos investigar el papel que jugar\u00eda la melatonina sobre dos enfermedades autounmunes, la artritis reumatoide y el lupus eritematoso sist\u00e9mico.  la administraci\u00f3n de melatonina en ratas , con artritis inducida pro col\u00e1geno resulto tener efectos perjudiciales por elevar los niveles de anticuerpos anti col\u00e1geno , elev\u00f3 los niveles de citoquinas inflematorias 11-1 e 11-6 que contribuyen a la degradaci\u00f3n y eroti\u00f3n del cart\u00edlago , no reduce los niveles de stress oxidativo uo y lpo y motr\u00edfica los niveles hormonales:aumentando el cortisol y modificando la produci\u00f3n de mormonas sexuales.  la administraci\u00f3n de malatona en ratones mrl-lpr resulto tener efectos opuestos seg\u00fan el sexo en hembras , la administraci\u00f3n de melatonina posee efectos beneficiosos porque reduce los niveles de autoantiguerpos y provoca un cambio del respuesta del tipo th2 antinflamatiria en machos poseee efectos perjudiciales por tener una respuesta proinflamator\u00eda con elevaci\u00f3n de los niveles de autoanticuerpos la melatonina act\u00faa en el lupus de modo directo a nivel celular y demodo indirecto sobre la producci\u00f3n de mormonas sexuales, seguramente a trav\u00e9s de la gnrh.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acci\u00f3n de la melatonina en las enfermedades autoinmunes: artritis reumatoide y lupus eritemaposo sit\u00e9mico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acci\u00f3n de la melatonina en las enfermedades autoinmunes: artritis reumatoide y lupus eritemaposo sit\u00e9mico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Jim\u00e9nez Caliani Antonio  Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Osuna Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Guerrero mont\u00e1vez Juan  Miguel <\/li>\n<li> Segura ayestaran m. dolores (vocal)<\/li>\n<li>Juan  ram\u00f3n Calvo guti\u00e9rrez (vocal)<\/li>\n<li>Jes\u00fas Castillo g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jim\u00e9nez Caliani Antonio Javier Recientemente se ha abierto y descubierto un nuevo campo de estudio de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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