{"id":72792,"date":"2018-03-09T23:17:38","date_gmt":"2018-03-09T23:17:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/acoplamiento-intramolecular-en-pirazoles-15-disustituidos-sintesis-de-nuevos-sistemas-pirazoloheterociclicos\/"},"modified":"2018-03-09T23:17:38","modified_gmt":"2018-03-09T23:17:38","slug":"acoplamiento-intramolecular-en-pirazoles-15-disustituidos-sintesis-de-nuevos-sistemas-pirazoloheterociclicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/acoplamiento-intramolecular-en-pirazoles-15-disustituidos-sintesis-de-nuevos-sistemas-pirazoloheterociclicos\/","title":{"rendered":"Acoplamiento intramolecular en pirazoles 1,5 disustituidos. sintesis de nuevos sistemas pirazoloheterociclicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Hernandez Cuadrado <\/strong><\/h2>\n<p>En la presente memoria se describe la preparaci\u00f3n de pirazolo[1,5-f]fenantridinas, dibenzo[b,f]pirazolo[1,5-d][1,4]diazepinas y pirazolo[1,5-a](benzo)tienoquinolinas, siendo la etapa clave de su s\u00edntesis la formaci\u00f3n de un enlace biar\u00edlico, carom-n o aril-heteroar\u00edlico respectivamente a trav\u00e9s de reacciones catalizadas por paladio. Los intermedios que permiten el acceso a dichos sistemas polic\u00edclicos son en todos los casos pirazoles 1,5-disustituidos, preparados por medio de un proceso tandem de intercambio am\u00ednico\/heterociclaci\u00f3n entre enaminocetonas e hidrazinas.  en lo que respecta a las pirazolo[1,5-f]fenantridinas la formaci\u00f3n del enlace biar\u00edlico presente en la mol\u00e9cula se realiza a partir de 1-aril-5-(2-bromoaril)pirazoles bajo condiciones de cat\u00e1lisis de paladio tanto homog\u00e9nea como heterog\u00e9nea. como v\u00eda alternativa\/complementaria, la preparaci\u00f3n del tetraciclo se efect\u00faa asimismo en condiciones radicalarias.  por otra parte, para la s\u00edntesis de las dibenzo[b,f]pirazolo[1,5-d]diazepinas se requiere la formaci\u00f3n de un enlace carom-n, proceso realizado bajo cat\u00e1lisis de paladio tanto homog\u00e9nea como heterog\u00e9nea a partir de 1-(2-bromoaril)-5-(2-aminoaril)pirazoles.  finalmente, adem\u00e1s del inter\u00e9s de los productos generados y de las secuencias sint\u00e9ticas empleadas, debe destacarse el hecho de que el acoplamiento intramolecular catalizado por paladio conducente a los sistemas pirazolo[1,5-a]tienoquinol\u00ednico y pirazolo[1,5-a]benzotienoquinol\u00ednico tiene lugar entre fragmentos haloheteroar\u00e9nico y ar\u00e9nico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acoplamiento intramolecular en pirazoles 1,5 disustituidos. sintesis de nuevos sistemas pirazoloheterociclicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acoplamiento intramolecular en pirazoles 1,5 disustituidos. sintesis de nuevos sistemas pirazoloheterociclicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Hernandez Cuadrado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/02\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raul Sanmartin Faces<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bruno Danieli <\/li>\n<li>Antonio Mouri\u00f1o mosquera (vocal)<\/li>\n<li>Rafael Pedrosa saez (vocal)<\/li>\n<li>esther Lete exposito (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Hernandez Cuadrado En la presente memoria se describe la preparaci\u00f3n de pirazolo[1,5-f]fenantridinas, dibenzo[b,f]pirazolo[1,5-d][1,4]diazepinas y pirazolo[1,5-a](benzo)tienoquinolinas, siendo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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