{"id":72906,"date":"2018-03-09T23:17:47","date_gmt":"2018-03-09T23:17:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-del-gen-matl1-como-oncogen-dominante-en-el-linfoma-malt\/"},"modified":"2018-03-09T23:17:47","modified_gmt":"2018-03-09T23:17:47","slug":"identificacion-del-gen-matl1-como-oncogen-dominante-en-el-linfoma-malt","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/identificacion-del-gen-matl1-como-oncogen-dominante-en-el-linfoma-malt\/","title":{"rendered":"\u00abidentificaci\u00f3n del gen matl1 como oncog\u00e9n dominante en el linfoma malt\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez Izquierdo Mar\u00eda Dolores <\/strong><\/h2>\n<p>En los linfomas no hodgkin (lnh), las traslocaciones primarias caracter\u00edsticas dan lugar a la desregulaci\u00f3n de un protooncog\u00e9n (debido en un gran n\u00famero de casos al reordenamiento con el gen de las inmunoglobulinas) y cuya consecuencia funcional es la alteraci\u00f3n de la expresi\u00f3n g\u00e9nica con potencial neopl\u00e1sico. otro tipo de lesi\u00f3n gen \u00e9tica frecuente es la delecci\u00f3n cromos\u00f3mica que inactiva genes supresores tumorales, por ejemplo p53 \u00f3 pl6. Estas anomal\u00edas se identifican junto a las traslocacione primarias y se consideran alteraciones secundarias relacionadas con la progresi\u00f3n y transformaci\u00f3n tumoral. Tambi\u00e9n la amplificaci\u00f3n g\u00e9nica es otro mecanismo de reordenamiento molecular frecuente en los lnh ( oncogenes rel, c- myc, y bcl2). La hibridaci\u00f3n in situ con fluorescencia (fish) es el v\u00ednculo entre citogen\u00e9tica y biolog\u00eda molecular. ha permitido establecer la relaci\u00f3n entre una determinada alteraci\u00f3n a nivel del cromo soma y su correspondiente regi\u00f3n gen\u00f3mica, con la identificaci\u00f3n final de los genes implicados. Esta tesis engloba tres trabajos cuyo objetivo ha sido detectar y caracterizar reordenamientos moleculares espec\u00edficos de varios tipos de lnh. En el primer art\u00edculo se desarrollan sondas flanquantes dellocus correspondiente al gen bcl6 que permiten detectar todas sus posibles traslocaciones. Este gen se encuentra alterado en un 40% de los casos de linfoma difuso de c\u00e9lula grande, sin que este a\u00fan claro su valor pron\u00f3stico. en el segundo art\u00edculo se detectan reordenamientos espec\u00edficos que podr\u00edan implicarse en la progresi\u00f3n del linfoma espl\u00e9nico de la zona marginal: trisom\u00eda 3 y reordenamientos en 19p13 y 7p22-q22. En el tercer art\u00edculo el estudio molecular de dos casos de linfoma mal t con t(14;18) ha permitido el clonaje de un nueva traslocaci\u00f3n citogen\u00e9tica que afecta al gen maltl, una paracaspasa implicada en la respuesta inmune y en la se\u00f1alizaci\u00f3n a trav\u00e9s de nf-kb. Tambi\u00e9n se demu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abidentificaci\u00f3n del gen matl1 como oncog\u00e9n dominante en el linfoma malt\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abidentificaci\u00f3n del gen matl1 como oncog\u00e9n dominante en el linfoma malt\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez Izquierdo Mar\u00eda Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/02\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Conde Bru Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosa De frutos ill\u00e1n <\/li>\n<li>Juan  cruz Cigudosa garcia (vocal)<\/li>\n<li>Antonio Fern\u00e1ndez izquierdo (vocal)<\/li>\n<li>francesc Sol\u00e9 ristol (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez Izquierdo Mar\u00eda Dolores En los linfomas no hodgkin (lnh), las traslocaciones primarias caracter\u00edsticas dan lugar a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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