{"id":72910,"date":"2018-03-09T23:17:47","date_gmt":"2018-03-09T23:17:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonacion-molecular-y-estudio-funcional-de-la-proteina-snd-p102-de-hepatocito-de-rata\/"},"modified":"2018-03-09T23:17:47","modified_gmt":"2018-03-09T23:17:47","slug":"clonacion-molecular-y-estudio-funcional-de-la-proteina-snd-p102-de-hepatocito-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/clonacion-molecular-y-estudio-funcional-de-la-proteina-snd-p102-de-hepatocito-de-rata\/","title":{"rendered":"Clonacion molecular y estudio funcional de la proteina snd p102 de hepatocito de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Palacios Martin <\/strong><\/h2>\n<p>Este trabajo aborda la identificaci\u00f3n de la prote\u00edna de rata purificada en nuestro laboratorio que se denomin\u00f3 erceh (colesterol \u00e9ster hidrolasa de ret\u00edculo endopl\u00e1smico) y su posible papel en el metabolismo lip\u00eddico de los hepatocitos. Su secuencia aminoac\u00eddica revel\u00f3 que la prote\u00edna pertenece a la familia de prote\u00ednas que presentan 4 dominios snc (staphiloccocus nuclease) y 1 dominio tudor. No se encontraron suficientes indicios para atribuirle una actividad colesterol \u00e9ster hidrolasa, por lo que ha sido redenominada como snd p102. En hepatocitos y c\u00e9lulas hepg2 y cho se ha inmunolocalizado b\u00e1sicamente en citoplasma, preferentemente en microsomas. mediante infecci\u00f3n adenoviral de hepatocitos de rata para sobreexpresar o anular la expresi\u00f3n de la prote\u00edna snd p102 se ha visto su implicaci\u00f3n en la movilizaci\u00f3n del fosfol\u00edpido desde el citoplasma hacia v\u00edas secretoras, principalmente la secreci\u00f3n biliar, aunque tambi\u00e9n hacia la secreci\u00f3n de lipoprote\u00ednas, sin afectar al n\u00c2\u00ba de part\u00edculas de vldl secretadas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Clonacion molecular y estudio funcional de la proteina snd p102 de hepatocito de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Clonacion molecular y estudio funcional de la proteina snd p102 de hepatocito de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Palacios Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/02\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fresnedo Aranguren  M. Olatz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Goiriena de gandarias Juan  jose <\/li>\n<li>carles Enrich bast\u00fas (vocal)<\/li>\n<li>vicente Castell jose (vocal)<\/li>\n<li> Gomez lechon Mar\u00eda  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Palacios Martin Este trabajo aborda la identificaci\u00f3n de la prote\u00edna de rata purificada en nuestro laboratorio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,964,12909,17],"tags":[19134,71783,13079,97701,158403,158404],"class_list":["post-72910","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-lipidos","category-pais-vasco-euskal-herriko-unibertsitatea","category-quimica","tag-carles-enrich-bastus","tag-fresnedo-aranguren-m-olatz","tag-goiriena-de-gandarias-juan-jose","tag-gomez-lechon-maria-jose","tag-lourdes-palacios-martin","tag-vicente-castell-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72910"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72910\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}