{"id":72966,"date":"2018-03-09T23:17:51","date_gmt":"2018-03-09T23:17:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-proteinas-relacionadas-con-la-resistencia-a-multiples-drogas-mdr-proteinas-en-cancer-de-pulmon\/"},"modified":"2018-03-09T23:17:51","modified_gmt":"2018-03-09T23:17:51","slug":"expresion-de-proteinas-relacionadas-con-la-resistencia-a-multiples-drogas-mdr-proteinas-en-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-de-proteinas-relacionadas-con-la-resistencia-a-multiples-drogas-mdr-proteinas-en-cancer-de-pulmon\/","title":{"rendered":"Expresion de proteinas relacionadas con la resistencia a multiples drogas (mdr proteinas) en cancer de pulmon"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfredo Paredes Lario <\/strong><\/h2>\n<p>La mayor\u00eda de pacientes con c\u00e1ncer de pulm\u00f3n suelen ser resistentes al tratamiento quimioter\u00e1pico. En estudios experimentales con cultivos celulares, la expresi\u00f3n de determinadas prote\u00ednas transportadoras, conocidas como \u00abprote\u00ednas relacionadas con la resistencia a m\u00faltiples drogas o mdr-prote\u00ednas\u00bb, confiere resistencia a m\u00faltiples f\u00e1rmacos antineopl\u00e1sicos.  en esta tesis doctoral, por m\u00e9todos inmunohistoqu\u00edmicos, hemos estudiado la expresi\u00f3n de tres de estas prote\u00ednas (pgp, mrp1 y lrp), en muestras tumorales criocongeladas de 99 pacientes con c\u00e1ncer de pulm\u00f3n sin tratamiento quimioter\u00e1pico previo: 93 carcinomas de c\u00e9lula no peque\u00f1a (49 escamosos, 37 adenocarcinomas, 7 c\u00e9l. Grande 3 carcinomas de c\u00e9lula peque\u00f1a, 3 otras histolog\u00edas) .  nuestros resultados revelan una importante expresi\u00f3n de las tres mdr-prote\u00ednas, con un 64%, 49% y 38% de los pacientes expresando lrp, pgp y mrp1 respectivamente, y un 66% de ellos expresando simult\u00e1neamente m\u00e1s de una mdr-prote\u00edna. No hemos encontrado diferencias de expresi\u00f3n en relaci\u00f3n a variables cl\u00ednico-patol\u00f3gicas como la edad, estadio, grado de diferenciaci\u00f3n histol\u00f3gico o supervivencia, pero s\u00ed existen variaciones entre los diferentes tipos histol\u00f3gicos, destacando una baja expresi\u00f3n de mrp1 en los adenocarcinomas (p=0.000). Las prote\u00ednas pgp y lrp suelen expresarse asociadas ((p=0.000). Los pacientes que expresan simult\u00e1neamente pgp y mrp1 responden significativamente peor al tratamiento quimioter\u00e1pico (p=0.0<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de proteinas relacionadas con la resistencia a multiples drogas (mdr proteinas) en cancer de pulmon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de proteinas relacionadas con la resistencia a multiples drogas (mdr proteinas) en cancer de pulmon <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfredo Paredes Lario <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/02\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Echenique Elizondo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Val bernal Jos\u00e9 Francisco <\/li>\n<li>Jaime Mendez martin (vocal)<\/li>\n<li>ignacio Iturburu belmonte (vocal)<\/li>\n<li> Garijo ayensa Mar\u00eda  francisca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfredo Paredes Lario La mayor\u00eda de pacientes con c\u00e1ncer de pulm\u00f3n suelen ser resistentes al tratamiento quimioter\u00e1pico. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,69,189,484,139,1027,347,12909,156],"tags":[158523,10586,158525,10122,12925,158524],"class_list":["post-72966","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-enfermedades-pulmonares","category-farmacodinamia","category-mecanismos-de-accion-de-la-quimioterapia","category-medicina-interna","category-oncologia","category-oncologia-clinica","category-pais-vasco-euskal-herriko-unibertsitatea","category-patologia","tag-alfredo-paredes-lario","tag-garijo-ayensa-maria-francisca","tag-ignacio-iturburu-belmonte","tag-jaime-mendez-martin","tag-miguel-echenique-elizondo","tag-val-bernal-jose-francisco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=72966"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/72966\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=72966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=72966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=72966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}