{"id":72991,"date":"2005-02-03T00:00:00","date_gmt":"2005-02-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-del-huesped-que-afectan-a-la-progresion-de-la-infeccion-por-el-virus-de-la-inmunodeficiencia-humana-tipo-i-vih-1\/"},"modified":"2005-02-03T00:00:00","modified_gmt":"2005-02-03T00:00:00","slug":"factores-del-huesped-que-afectan-a-la-progresion-de-la-infeccion-por-el-virus-de-la-inmunodeficiencia-humana-tipo-i-vih-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-del-huesped-que-afectan-a-la-progresion-de-la-infeccion-por-el-virus-de-la-inmunodeficiencia-humana-tipo-i-vih-1\/","title":{"rendered":"Factores del hu\u00e9sped que afectan a la progresi\u00f3n de la infecci\u00f3n por el virus de la inmunodeficiencia humana tipo i (vih-1)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anuska Llano Montero <\/strong><\/h2>\n<p>La infecci\u00f3n del vih-1 se caracteriza por la depleci\u00f3n selectiva de las c\u00e9lulas t cd4 positivas, siendo este ant\u00edgeno necesario para que se produzca la infecci\u00f3n de las c\u00e9lulas; sin embargo, la presencia de cd4 no es suficiente, sino que se requiere la presencia de otro co-receptor para que se produzca la infecci\u00f3n. Los dos principales co-receptores empleados por el vih-1 son cxcr4 y ccr5. Ambos son receptores de quimiocinas, que pertenecen a la superfamilia de receptores de site dominios transmembrana acoplados a prote\u00ednas g.  la infecci\u00f3n del vih-1 in vivo se puede dividir en tres etapas: la fase aguda que corresponde a la primo-infecci\u00f3n, la fase cr\u00f3nica, que se caracteriza por una latencia inmunol\u00f3gica, pero no virol\u00f3gica y la fase cr\u00edtica o sida. las dos primeras fases de la infecci\u00f3n se caracterizan por la presencia de las presencia de las cepas virales r5, que son aquellas que utilizan como co-receptor para la entrada a ccr5. La \u00faltima fase de la infecci\u00f3n se caracteriza, en el 50% de los casos, por la presencia de la cepa viral x4, que emplea cxcr4 para entrar en la c\u00e9lula. Sin embargo, no se conocen las causan exactas de la aparici\u00f3n de estas variantes m\u00e1s patog\u00e9nicas y como se correlaciona este hecho con la exprexi\u00f3n del receptor cxcr4 in vivo.  las quimiocinas juegan un papel importante en la infecci\u00f3n por el vih-1, rantes, mip-1alfa y mip-1beta, ligandos naturales de ccr5, inhiben la infecci\u00f3n in vitro de las variantes r5; mientras que sdf-1, ligando natural de cxcr4, inhibe la infecci\u00f3n de las variantes x4. La progresi\u00f3n de la infecci\u00f3n se caracteriza por la p\u00e9rdida progresiva de c\u00e9lulas t cd4 durante la fase cr\u00f3nica, con la aparici\u00f3n de las variantes x4 dicha depleci\u00f3n es m\u00e1s r\u00e1pida y acusada. La citocina il-7 es clave en el desarrollo de c\u00e9lulas t y adem\u00e1s in vitro induce la sobre-expresi\u00f3n del receptor cxcr4, todo esto hace de il-7 un factor importante tanto en la progresi\u00f3n como en l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores del hu\u00e9sped que afectan a la progresi\u00f3n de la infecci\u00f3n por el virus de la inmunodeficiencia humana tipo i (vih-1)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores del hu\u00e9sped que afectan a la progresi\u00f3n de la infecci\u00f3n por el virus de la inmunodeficiencia humana tipo i (vih-1) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anuska Llano Montero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Andr\u00e9s Est\u00e9 Araque<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lidia Ruiz <\/li>\n<li>manel Juan  otero (vocal)<\/li>\n<li>pere-joan Cardona (vocal)<\/li>\n<li>montse Plana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anuska Llano Montero La infecci\u00f3n del vih-1 se caracteriza por la depleci\u00f3n selectiva de las c\u00e9lulas t 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