{"id":73003,"date":"2005-03-03T00:00:00","date_gmt":"2005-03-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-funcionales-de-los-receptores-beta-2-adrenergicos-en-pacientes-cirroticos-con-hipertension-portal\/"},"modified":"2005-03-03T00:00:00","modified_gmt":"2005-03-03T00:00:00","slug":"cambios-funcionales-de-los-receptores-beta-2-adrenergicos-en-pacientes-cirroticos-con-hipertension-portal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cambios-funcionales-de-los-receptores-beta-2-adrenergicos-en-pacientes-cirroticos-con-hipertension-portal\/","title":{"rendered":"Cambios funcionales de los receptores beta 2 adrenergicos en pacientes cirroticos con hipertension portal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Hernandez Rocamora Flavia Tamara <\/strong><\/h2>\n<p>El sangrado por varices esof\u00e1gicas constituye la complicaci\u00f3n m\u00e1s com\u00fan y letal en pacientes con cirrosis e hipertension portal (htp) . Hasta un tercio de los pacientes con varices sangrar\u00e1 durante los 2 primeros a\u00f1os y, aunque este sangrado inicial se detiene espont\u00e1neamente en el 60-70% de los casos, la mortalidad inicial oscila entre un 30 y 70%.  el tratamiento de elecci\u00f3n en estos pacientes cirr\u00f3ticos con htp son los f\u00e1rmacos beta-bloqueantes no selectivos aunque diversos autores han propuesto que la respuesta que muestran los pacientes al tratamiento es bastante escasa y heterog\u00e9nea.  no se conocen las causas o mecanismos por los que los pacientes no responden al tratamiento aunque se ha postulado que podr\u00eda influir ciertos factores del paciente (grado de da\u00f1o hep\u00e1tico), factores farmacocin\u00e9ticos y factores farmacodin\u00e1micos (descenso en el n\u00famero de receptores beta-adren\u00e9rgicos).  dado que los fen\u00f3menos anteriores no explican con claridad las causas por las que los pacientes no responden al tratamiento con propranolol, nuestro equipo se plante\u00f3 el estudio de este fen\u00f3meno evaluando la funcionalidad de los receptores beta-2 adren\u00e9rgicos. Como modelo de estudio se utilizaron membranas de hemat\u00edes de pacientes cirr\u00f3ticos con htp y como indicador de la funcionalidad se us\u00f3 la producci\u00f3n de ampc en respuesta a un est\u00edmulo adren\u00e9rgico con isoproterenol tanto en ausencia como en presencia de propranolol.  los resultados de este trabajo muestran, de acuerdo con la hip\u00f3tesis inicial, que existen cambios en la actividad funcional de los receptores beta-2 adrenergicos y del sistema de la adenilato ciclasa (ac) en los pacientes cirr\u00f3ticos con htp, siendo estos cambios dependientes de la evoluci\u00f3n de los pacientes. Concretamente hemos visto que la actividad funcional de la ac en membranas de eritrocitos maduros de pacientes cirr\u00f3ticos con varices esof\u00e1gicas e htp, es significativamente superior a lo observado e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios funcionales de los receptores beta 2 adrenergicos en pacientes cirroticos con hipertension portal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios funcionales de los receptores beta 2 adrenergicos en pacientes cirroticos con hipertension portal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Hernandez Rocamora Flavia Tamara <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Francisco Horga De La Parte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garcia garcia <\/li>\n<li>Jos\u00e9 Mar\u00eda Palazon azorin (vocal)<\/li>\n<li>Miguel Perez mateo regadera (vocal)<\/li>\n<li>magdalena Hernandez sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hernandez Rocamora Flavia Tamara El sangrado por varices esof\u00e1gicas constituye la complicaci\u00f3n m\u00e1s com\u00fan y letal en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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