{"id":73068,"date":"2005-07-03T00:00:00","date_gmt":"2005-07-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-hormonas-tiroideas-en-la-migracion-de-neuronas-gabaergicas-de-la-corteza-cerebral-efecto-de-la-hipotiroxinemia-materna\/"},"modified":"2005-07-03T00:00:00","modified_gmt":"2005-07-03T00:00:00","slug":"papel-de-las-hormonas-tiroideas-en-la-migracion-de-neuronas-gabaergicas-de-la-corteza-cerebral-efecto-de-la-hipotiroxinemia-materna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-de-las-hormonas-tiroideas-en-la-migracion-de-neuronas-gabaergicas-de-la-corteza-cerebral-efecto-de-la-hipotiroxinemia-materna\/","title":{"rendered":"Papel de las hormonas tiroideas en la migracion de neuronas gabaergicas de la corteza cerebral. efecto de la hipotiroxinemia materna"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Estela Cuevas Romero <\/strong><\/h2>\n<p>La hipotiroxinemia materna leve y transitoria afecta la distribuci\u00f3n radial de neuronas glutamat\u00e9rgicas en la neocorteza de las cr\u00edas e induce un menor umbral a presentar crisis audiog\u00e9nicas. Se desconoce si la migraci\u00f3n radial y tangencial de las c\u00e9lulas gaba\u00e9rgicas pudiese tambi\u00e9n ser afectada. En ratas y ratonas gestantes se indujo un estado de hipotiroxinemia materna mediante administraci\u00f3n de metimazol. El an\u00e1lisis de la distribuci\u00f3n radial de c\u00e9lulas gaba\u00e9rgicas en la neocorteza de las cr\u00edas, usando marcadores inmunohistoqu\u00edmicos (palvalb\u00famina, calbindina, calretinina y \u00f3xido n\u00edtrico sintetasa), mostr\u00f3 que la distribuci\u00f3n radial de los diferentes subtipos de neuronas gaba\u00e9rgicas en la neocorteza es similar entre las cr\u00edas de madres normales y de madres hipotiroxin\u00e9micas. En cambio, el an\u00e1lisis de la migraci\u00f3n tangencial de c\u00e9lulas de la eminencia ganglionar medial (egm) en la neocorteza, usando co-cultivos organot\u00edpicos, mostr\u00f3 que las neuronas provenientes tanto de explantes de egm de embriones de madres normales como de madres hipotiroxin\u00e9micas migran preferentemente hacia la regi\u00f3n medial versus lateral  de la neocorteza, mientras que, las neuronas tanto de explantes de egm de embriones de madres normales como de madres hipotiroxin\u00e9micas pierden la preferencia por la regi\u00f3n medial. Estos resultados sugieren que la hipotiroxinemia materna no parece afectar la migraci\u00f3n radial de las c\u00e9lulas gaba\u00e9rgicas en la neocorteza, pero s\u00ed afecta su migraci\u00f3n tangencial. en esta \u00faltima, la hipotiroxinemia materna pudiese alterar las se\u00f1ales atrayentes o respulsivas del sustrato (neocorteza), causando la desorientaci\u00f3n de las neuronas de la egm.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las hormonas tiroideas en la migracion de neuronas gabaergicas de la corteza cerebral. efecto de la hipotiroxinemia materna<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las hormonas tiroideas en la migracion de neuronas gabaergicas de la corteza cerebral. efecto de la hipotiroxinemia materna <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Estela Cuevas Romero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/03\/2005<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pere Berbel Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gabriella Morreale  de castro <\/li>\n<li>Carlos Lopez garcia (vocal)<\/li>\n<li>Juan Bernal carrasco (vocal)<\/li>\n<li>Javier Defelipe oroquieta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Estela Cuevas Romero La hipotiroxinemia materna leve y transitoria afecta la distribuci\u00f3n radial de neuronas glutamat\u00e9rgicas en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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